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Hypertension:高血压持续时间和程度以及体重对新发房颤的影响

2019-09-16 xing.T MedSci原创

总之,高血压的程度和持续时间以及高血压的存在是新发AF的重要因素。体重状态与新发AF显著相关,并与高血压具有协同作用。

高血压和肥胖是房颤(AF)已知的危险因素。然而,尚不清楚不受控制的慢性高血压是否对房颤产生特别深远的影响。因为它们具有相似的潜在病理生理学机制,所以在AF的情况下,高血压和肥胖可以产生协同作用。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员评估了高血压和体重状态的各个阶段如何影响新发AF。

研究人员分析了9797418名参与者,他们接受了全国健康检查。高血压分为5个阶段:非高血压、高血压前期、无药物治疗的高血压、药物治疗<5年高血压,药物治疗≥5年高血压。参与者还根据体重指数和腰围进行分层。

在80130161人次每年的随访期间,共有196136例新发AF患者。在高血压5个阶段的人群中,新发AF的发病率逐渐增加:高血压各阶段调整风险比分别为1(参考)、1.145、1.390、1.853和2.344。随着收缩压和舒张压的增加,也观察到新发AF风险升级。新发AF的发生率与体重指数和腰围相关,肥胖者的风险高于其他人。高血压和肥胖之间具有协同作用:服用≥5年的高血压伴肥胖者患AF的风险最高。

总之,高血压的程度和持续时间以及高血压的存在是新发AF的重要因素。体重状态与新发AF显著相关,并与高血压具有协同作用。 

原始出处:

Yun Gi Kim.et al.Impact of the Duration and Degree of Hypertension and Body Weight on New-Onset Atrial Fibrillation A Nationwide Population-Based Study.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13672

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    2020-04-02 hb2008ye
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    2020-05-19 zhaojie88
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