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Aesthet Surg J:A型肉毒杆菌毒素可显著减小下眼睑疤痕

2021-10-15 MedSci原创 MedSci原创

下眼睑整形术是一种常见的美容手术,主要依赖于术后疤痕极小,但亚洲患者比白种人更容易出现瘢痕肥厚和/或扩大。A型肉毒杆菌毒素(BTX)注射被广泛用于缓解面部动态皱纹,也可以通过减少疤痕张力来改善疤痕大小

下眼睑整形术是一种常见的美容手术,主要依赖于术后疤痕极小,但亚洲患者比白种人更容易出现瘢痕肥厚和/或扩大。A型肉毒杆菌毒素(BTX)注射被广泛用于缓解面部动态皱纹,也可以通过减少疤痕张力来改善疤痕大小。近日,发表于Aesthet Surg J的一项前瞻性、随机、载体对照、双盲的临床试验评估了经皮下眼睑整形术和BTX注射是否能改善眼下疤痕的大小。

研究在2015年5月至2018年5月期间进行,纳入了40名接受双侧经皮下眼睑整形术的成人患者,随机分配到伤口闭合后立即接受BTX(n = 20)或载体(正常生理盐水;n = 20)注射到外侧眼轮匝肌。在最后的临床随访中,记录了温哥华疤痕量表、视觉模拟量表和3个参考点的疤痕宽度摄影测量。

 

结果,共37名患者完成了试验。实验组和载体对照组的温哥华疤痕量表(实验组和对照组分别为4.72±2.48 vs 4.65±2.70;P = 0.898)和视觉模拟量表(实验组和对照组分别为6.41±2.01 vs 6.42±1.99;P = 0.993)得分相似,但实验组所有测量点的疤痕宽度都明显比对照组窄(每个测量点的P < 0.001,P = 0.027,P < 0.001)。

综上所述,该研究结果表明,亚洲人的经皮下眼睑整形术所形成的疤痕可通过同时注射BTX来明显缩窄瘢痕,且无额外并发症。建议进行外侧眼角切除术,以防止睑外翻。

 

原始出处:

 

Yau-Li Huang, et al., Botulinum Toxin to Improve Lower Blepharoplasty Scar: A Double-Blinded, Randomized, Vehicle-Controlled Clinical Trial. Aesthet Surg J. 2021 Aug 13;41(9):1003-1010. doi: 10.1093/asj/sjab024.

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21 17:07:41 CST 2021, time=2021-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061512, encodeId=5848106151285, content=已学, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a4d75638647, createdName=YHW, createdTime=Mon Oct 18 16:13:31 CST 2021, time=2021-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394130, encodeId=eb2c139413037, content=<a href='/topic/show?id=7b29e0460b1' target=_blank style='color:#2F92EE;'>#疤痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70460, encryptionId=7b29e0460b1, topicName=疤痕)], attachment=null, authenticateStatus=null, 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style='color:#2F92EE;'>#肉毒杆菌毒素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80855, encryptionId=943e8085574, topicName=肉毒杆菌毒素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5efb13261288, createdName=wsusan1970, createdTime=Sun Oct 17 03:14:20 CST 2021, time=2021-10-17, status=1, ipAttribution=)]
    2021-11-28 245462683

    谢谢评论

    0

  5. 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21 17:07:41 CST 2021, time=2021-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061512, encodeId=5848106151285, content=已学, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a4d75638647, createdName=YHW, createdTime=Mon Oct 18 16:13:31 CST 2021, time=2021-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394130, encodeId=eb2c139413037, content=<a href='/topic/show?id=7b29e0460b1' target=_blank style='color:#2F92EE;'>#疤痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70460, encryptionId=7b29e0460b1, topicName=疤痕)], attachment=null, authenticateStatus=null, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=2081041, encodeId=4f422081041b5, content=<a href='/topic/show?id=c5092015926' target=_blank style='color:#2F92EE;'>#下眼睑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20159, encryptionId=c5092015926, topicName=下眼睑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Wed Jul 13 23:14:20 CST 2022, time=2022-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684115, encodeId=921f168411573, content=<a href='/topic/show?id=bf59e2814cf' target=_blank style='color:#2F92EE;'>#眼睑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72814, encryptionId=bf59e2814cf, topicName=眼睑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d8928034409, 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/qXbLjJB4FSzhQS3C5qQFMJkqicRIJFL6zHFwwhv0I95nzA6xicevQcEica0gk4A58UkbMMriadAgTY2b7N7Yd0ZsQg/132, createdBy=910c2500152, createdName=HinsMax, createdTime=Sun Oct 17 03:14:20 CST 2021, time=2021-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521361, encodeId=a3171521361ef, content=<a href='/topic/show?id=34f38085491' target=_blank style='color:#2F92EE;'>#肉毒杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80854, encryptionId=34f38085491, topicName=肉毒杆菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=60f411331131, createdName=liubm559, createdTime=Sun Oct 17 03:14:20 CST 2021, time=2021-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540557, encodeId=3fb8154055e71, content=<a href='/topic/show?id=943e8085574' target=_blank style='color:#2F92EE;'>#肉毒杆菌毒素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80855, encryptionId=943e8085574, topicName=肉毒杆菌毒素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5efb13261288, createdName=wsusan1970, createdTime=Sun Oct 17 03:14:20 CST 2021, time=2021-10-17, status=1, ipAttribution=)]
    2021-10-21 云上的小日子

    学习了

    0

  7. 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21 17:07:41 CST 2021, time=2021-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061512, encodeId=5848106151285, content=已学, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a4d75638647, createdName=YHW, createdTime=Mon Oct 18 16:13:31 CST 2021, time=2021-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394130, encodeId=eb2c139413037, content=<a href='/topic/show?id=7b29e0460b1' target=_blank style='color:#2F92EE;'>#疤痕#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70460, encryptionId=7b29e0460b1, topicName=疤痕)], attachment=null, authenticateStatus=null, 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style='color:#2F92EE;'>#肉毒杆菌毒素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80855, encryptionId=943e8085574, topicName=肉毒杆菌毒素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5efb13261288, createdName=wsusan1970, createdTime=Sun Oct 17 03:14:20 CST 2021, time=2021-10-17, status=1, ipAttribution=)]
    2021-10-18 YHW

    已学

    0

  8. 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style='color:#2F92EE;'>#肉毒杆菌毒素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80855, encryptionId=943e8085574, topicName=肉毒杆菌毒素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5efb13261288, createdName=wsusan1970, createdTime=Sun Oct 17 03:14:20 CST 2021, time=2021-10-17, status=1, ipAttribution=)]
    2021-10-17 HinsMax
  9. 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