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BJC:转移性结直肠癌患者原发肿瘤部位对贝伐单抗联合化疗疗效的影响

2018-11-30 MedSci MedSci原创

两项一线贝伐单抗临床试验结果明确了原发肿瘤位置在转移性结直肠癌(mCRC)中的预后价值。BJC近期发表了一篇文章,在回顾性亚组分析中进一步分析了贝伐单抗的预测效果。

两项一线贝伐单抗临床试验结果明确了原发肿瘤位置在转移性直肠癌(mCRC)中的预后价值。BJC近期发表了一篇文章,在回顾性亚组分析中进一步分析了贝伐单抗的预测效果。

作者对两项贝伐单抗+化疗(CT)与单纯化疗比较治疗转移性直肠癌的随机III期临床试验的患者进行了回顾性分析。研究结果表明,2290名患者中有1590名(27%右侧和73%左侧)明确原发肿瘤位置。在左侧原发肿瘤和右侧原发肿瘤患者中,贝伐单抗+ 化疗与单纯化疗相比均可以改善患者无进展生存情况。同样,右侧转移性结直肠癌患者中贝伐单抗+化疗与单纯化疗相比总体生存率得到改善,但无统计学意义。左侧转移性结直肠癌患者显着改善。

文章最后认为,该研究结果表明贝伐单抗的治疗作用与转移性结直肠癌患者的肿瘤位置无关。

原始出处:

Fotios Loupakis, Herbert I. Hurwitz, et al. Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer BJC. November 2018 doi: https://doi.org/10.1038/s41416-018-0304-6

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    2019-01-23 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2018-11-30 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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2018年9月,发表在《J Clin Oncol》的一项开放标签、随机、III期研究(TAILOR研究)调查了RAS野生型转移性结直肠癌患者治疗过程中,西妥昔单抗联合亚叶酸、氟尿嘧啶和奥沙利铂(FOLFOX-4)vs FOLFOX-4的有效性和耐受性。

CLIN CANCER RES:循环肿瘤DNA出现RAS紧急突变对帕尼单抗治疗转移性结直肠癌的影响

抗EGFR治疗期间出现RAS突变可能是获得抗EGFR治疗耐药的机制,从而引起人们关注。循环肿瘤(ct)DNA检测是一种确定RAS突变状态的微创且高敏感的方法。CLIN CANCER RES近期发表了一篇文章,研究治疗期间循环肿瘤DNA出现RAS紧急突变对转移性结直肠癌治疗耐药的影响。

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