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EJC:转移性黑色素瘤患者中血浆总游离DNA作为肿瘤负担和预后评价的替代性标志物

2018-11-21 MedSci MedSci原创

一般来说,在肿瘤患者的血液中, cfDNA水平较高。而且高水平的cfDNA与患者的不良预后有关。然而,肿瘤负担难以测量,并且目前没有可靠的替代生物标记物来可靠地进行评价和确定。本研究的目的是评估血浆总细胞游离DNA作为肿瘤负荷和转移性黑素瘤患者预后的生物标志物的潜力。 研究人员开展了一项关于生物标志物的前瞻性队列研究。在43名转移性黑素瘤患者中进行了总血浆循环无细胞DNA(cfDNA)浓度

一般来说,在肿瘤患者的血液中, cfDNA水平较高。而且高水平的cfDNA与患者的不良预后有关。然而,肿瘤负担难以测量,并且目前没有可靠的替代生物标记物来可靠地进行评价和确定。本研究的目的是评估血浆总细胞游离DNA作为肿瘤负荷和转移性黑素瘤患者预后的生物标志物的潜力。

研究人员开展了一项关于生物标志物的前瞻性队列研究。在43名转移性黑素瘤患者中进行了总血浆循环无细胞DNAcfDNA)浓度的前瞻性生物标志物队列研究。作者对38个黑色素瘤患者采集了血液中的cfDNA,并对其中的33个病人进一步收集了ctDNA。与此同时,作者采集了这些患者的乳酸脱氢酶(LDH)浓度、肾小球滤过率(GFR)以及白细胞计数(WBC)。通过个体患者中所有转移性病变的三维放射学测量的体积总和计算肿瘤负荷。采用多元线性回归,研究了cfDNA与肿瘤体积之间的关系。

研究显示,基线cfDNA浓度与治疗前肿瘤负荷相关(ρ= 0.52P  <0.001)。基线cfDNA水平与死亡危险和总生存率显著相关,截止值89 pg /μl的可鉴定两个不同的预后组(高cfDNAHR = 2.22P= 0.004)。cfDNA89pg/μl的患者OS较短(10.0vs22.7个月,P = 0.009;cfDNAHR = 2.22P= 0.004),并且在多变量分析中与乳酸脱氢酶(LDH)相比,仍然显著性较强。此外,还发现了cfDNA的变化与治疗相关的肿瘤负荷变化之间的相关性(ρ= 0.49P = 0.002)。基线cfDNA和肿瘤负荷之间的比率是可预测的(cfDNA /肿瘤体积≥8pg /(μl* cm 3HR = 2.7 P= 0.024)。

研究表明,血浆cfDNA水平与肿瘤体积相关,是肿瘤负荷的替代生物标志物,也是转移性黑素瘤患者生存的预后标志物。

原始出处:

S.Valpione, Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2019-04-12 sunylz
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href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573577, encodeId=d3a115e35772a, content=<a href='/topic/show?id=ad6066363fb' target=_blank style='color:#2F92EE;'>#游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66363, encryptionId=ad6066363fb, topicName=游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d04c15907611, createdName=LSJ116, createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1680580, encodeId=42921680580ce, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Fri Apr 12 19:03:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841320, encodeId=c8e0184132098, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, 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encryptionId=bcd093445b5, topicName=转移性黑色素瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386442, encodeId=ca0113864420b, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444458, encodeId=1a71144445838, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, 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time=2018-11-23, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1680580, encodeId=42921680580ce, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Fri Apr 12 19:03:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841320, encodeId=c8e0184132098, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, 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channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558942, encodeId=152615589429e, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564951, encodeId=0490156495190, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573577, encodeId=d3a115e35772a, content=<a href='/topic/show?id=ad6066363fb' target=_blank style='color:#2F92EE;'>#游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66363, encryptionId=ad6066363fb, topicName=游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d04c15907611, createdName=LSJ116, createdTime=Fri Nov 23 06:03:00 CST 2018, time=2018-11-23, status=1, ipAttribution=)]
    2018-11-23 huagfeg
  7. 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time=2018-11-23, status=1, ipAttribution=)]
  8. 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time=2018-11-23, status=1, ipAttribution=)]
    2018-11-23 LSJ116

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