Thyroid：索拉非尼治疗晚期甲状腺髓样癌有效性和安全性评价

2016-02-18 Mechront 译 MedSci原创

研究者进行了一项研究，评估索拉非尼治疗晚期甲状腺髓样癌 (MTC)的有效性和安全性。该回顾性队列研究纳入了2011-12至2015-1月间的13名进展性转移的MTC患者，服用索拉非尼400 mg 两次/天。以索拉非尼治疗下的疾病缓解情况和无进展生存（PFS）作为主要结局指标。因为开始索拉非尼治疗后1周，出现严重皮肤过敏反应而排出了1名患者。12名转移性MTC患者的研究数据显示，参与者中位数年龄48

研究者进行了一项研究，评估索拉非尼治疗晚期甲状腺髓样癌 (MTC)的有效性和安全性。

该回顾性队列研究纳入了2011-12至2015-1月间的13名进展性转移的MTC患者，服用索拉非尼400 mg 两次/天。以索拉非尼治疗下的疾病缓解情况和无进展生存（PFS）作为主要结局指标。因为开始索拉非尼治疗后1周，出现严重皮肤过敏反应而排出了1名患者。

12名转移性MTC患者的研究数据显示，参与者中位数年龄48岁，10名为散发，还有2名为遗传学疾病。中位数治疗持续时间为11个月，中位数随访15.5个月。截至数据日，还有2（2/12 (16%)）名患者仍在使用索拉非尼治疗（分别16个月和34个月）。根据实体肿瘤的分析中的反应评估标准，有10(83.3%)名患者病情稳定，有2（16%）名疾病出现了进展，研究中没有观察到疾病对治疗药物的局部反应。中位数PFS为9个月。不过有3名患者在使用索拉非尼治疗后3个月内出现了广泛和快速进行性疾病，而导致了死亡。排除这3名死亡患者后，中位数PFS为12个月。有9（75%）名患者出现了不良事件，主要的不良事件包括皮肤毒性、体重下降和疲劳。有5（41.6%）名患者进行了药物减量，1名患者因为毒性而退出研究。

研究结果表明，使用索拉非尼治疗进展性转移的MTC患者具有较好的耐受性，可控制疾病进展，让75%的患者得到持久的临床效益。当凡德他尼和卡博替尼不可选时候，或这些药物治疗失败后，可以考虑选择索拉非尼进行治疗。

原始出处：

Castroneves LA, Negrão MV,et al.Sorafenib for the Treatment of Progressive Metastatic Medullary Thyroid Cancer: Efficacy and Safety Analysis.Thyroid. 2016 Feb 9. [Epub ahead of print]

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2016-04-22 忠诚向上

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值得学习

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2016-04-22 忠诚向上

值得学习

185 0
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2016-04-22 忠诚向上

值得学习

132 0
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2016-04-22 忠诚向上

值得学习

117 0
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2016-04-22 忠诚向上

值得学习

162 0
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2016-04-22 忠诚向上

值得学习

97 0
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2016-04-22 忠诚向上

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