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PLOS ONE:阿尔茨海默病患者甲状腺功能与脑血流量的关系

2019-04-05 海北 MedSci原创

据报道,甲状腺激素与认知能力下降以及阿尔茨海默病有关。最近的一项研究表明,正常范围内的甲状腺功能与阿尔茨海默病患者的脑血流量之间存在关系

据报道,甲状腺激素与认知能力下降以及阿尔茨海默病有关。最近的一项研究表明,正常范围内的甲状腺功能与阿尔茨海默病患者的脑血流量之间存在关系。轻度认知障碍通常是阿尔茨海默病的第一阶段。因此,早期诊断很重要。

最近的一项研究调查了轻度认知障碍和阿尔茨海默病患者甲状腺功能与局部脑血流量的关系。

共有122名接受甲状腺功能检查和单光子发射计算机断层扫描的记忆门诊患者,其被分为轻度认知障碍,阿尔茨海默病和正常组。在自动脑灌注单光子发射计算机断层扫描分析系统中,研究人员使用三维立体定位感兴趣区域模板,计算局部脑血流量。研究人员还进行了针对年龄和性别调整的多元回归分析,以检查甲状腺激素与局部脑血流之间的关系。

在轻度认知障碍组中,甲状腺刺激激素与双侧颞侧,双侧周围和双侧海马区域的局部脑血流显着相关。在阿尔茨海默病组,游离三碘甲状腺原氨酸与双侧顶叶,右侧颞叶和双侧周围区域的局部脑血流显着相关。

因此,该研究确认了轻度认知障碍组中甲状腺刺激素与局部脑血流量的关系,以及阿尔茨海默病组中游离三碘甲腺原氨酸与局部脑血流的关系。

这些研究结果可能有助于早期诊断轻度认知障碍和预防随后发展为阿尔茨海默病。


原始出处:

Nomoto S et al. The relationship between thyroid function and cerebral blood flow in mild cognitive impairment and Alzheimer's disease. PLOS ONE, 2019; doi: 10.1371/journal.pone.0214676. eCollection 2019.


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