J INTERN MED：乳糖酶持续性和牛奶摄入量与髋部骨折和骨密度！

2018-03-15 xing.T MedSci原创

由此可见，丹麦人群的遗传性终生乳糖酶耐受的高牛奶摄入量与髋部骨折无关。荟萃分析还表明，乳糖酶持续性与骨折风险无关。基因乳糖酶持续性与股骨颈骨密度增高有关，而与腰椎或全髋关节BMD无关。

牛奶摄入量与骨折风险降低之间是否存在因果关系尚不明确。近日，内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章，研究人员旨在检验一个假设即基因决定的牛奶摄入量降低了骨折风险和增加骨密度（BMD）。

研究人员在三个丹麦前瞻性研究（n=97811，年龄≥20岁）中分析了牛奶摄入量、乳糖耐受性相关的LCT-13910 C/T（rs4988235）（TT和TC）与髋部骨折之间的相关性。我们从5个发表的欧洲北部人口研究加入了LCT-13910和骨折和骨密度的荟萃分析。

在丹麦的研究中，牛奶摄入量每周增加1杯发生髋部骨折校正后的风险比（HR）为1（95%可信区间为0.99-1.01）。每个等位基因牛奶摄入量为0.58（0.49-0.68）。在丹麦研究的荟萃分析中，随机效应中TT vs. CC发生任何骨折的比值比为0.86（0.61-1.21；I2=73%）和TC vs. CC为0.90（0.68-1.21；I2=63%）。TT vs. CC在股骨颈BMD平均数标准差为0.10（0.02-0.18；I2=0%）g/cm2,TC vs. CC为0.06（-0.04至-0.17；I2=17%）g/cm2。腰椎或全髋关节骨密度与对照组比较差异无显著性。

由此可见，丹麦人群的遗传性终生乳糖酶耐受的高牛奶摄入量与髋部骨折无关。荟萃分析还表明，乳糖酶持续性与骨折风险无关。基因乳糖酶持续性与股骨颈骨密度增高有关，而与腰椎或全髋关节BMD无关。

原始出处：

Helle KM Bergholdt, Lactase persistence, milk intake, hip fracture, and bone mineral density: A study of 97,811 Danish individuals and a meta-analysis.J INTERN MED. 2018. http://onlinelibrary.wiley.com/doi/10.1111/joim.12753/full

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2018-12-21 spoonycyy

#牛奶摄入量#

76 0
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2018-03-18 liuyg0228

#持续性#

58 0
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2018-08-19 41514487@qq.com

#乳糖酶持续#

74 0
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2018-09-18 lmm397

#摄入量#

68 0
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2018-04-15 121f3903m94暂无昵称

好

104 0
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2018-04-14 121f3903m94暂无昵称

啊

118 0
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2018-04-06 121f3903m94暂无昵称

嗯

96 0
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2018-04-05 121f3903m94暂无昵称

啊

99 0
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2018-04-01 121f3903m94暂无昵称

好的

101 0
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2018-03-31 121f3903m94暂无昵称

谢谢分享

84 0

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