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JCEM:人离体胎盘灌注的皮质醇转移与代谢

2017-11-20 MedSci MedSci原创

大家都知道胎儿在宫内过度暴露于糖皮质激素与胎儿生长受限有关,也被认为是把胎儿非最佳生长与后期心血管疾病联系起来的关键机制。近日在JCEM上发表的一篇文章则旨在建立预测母儿糖皮质激素转移的模型。Laura I Stirrat等人假设胎盘11β- HSD2是产妇皮质醇转移到胎儿的主要限速步骤。

大家都知道胎儿在宫内过度暴露于糖皮质激素与胎儿生长受限有关,也被认为是把胎儿非最佳生长与后期心血管疾病联系起来的关键机制。近日在JCEM上发表的一篇文章则旨在建立预测母儿糖皮质激素转移的模型。Laura I Stirrat等人假设胎盘11β- HSD2是产妇皮质醇转移到胎儿的主要限速步骤。

研究人员在取自活体的胎盘灌注模型中用氚代皮质醇示踪剂,结合计算机模型,探讨皮质醇及其非活性代谢物可的松的互换在母婴皮质醇转移中所扮演的角色。研究人员从5名无妊娠并发症、择期剖宫产的的妇女中收集了足月胎盘,对离体胎盘的产妇动脉用D4皮质醇进行灌注,测定产妇和胎儿静脉流出的D4皮质醇、D3可的松和D3皮质醇含量。

研究结果显示随着D4皮质醇灌注浓度的增加,母体和胎儿静脉中的D4皮质醇、D3可的松和D3皮质醇含量均呈上升趋势。当11-βHSD活性被抑制时D3皮质醇合成收到抑制。在最高浓度时,只有3%的母体皮质醇转移到胎儿血液循环,而26.5%被代谢、70.5%通过母体静脉排出。抑制11β-HSD活性,转移至胎儿的皮质醇增加到7.3%,而92.7%通过母体静脉排出。

上述研究结果对母体皮质醇自由扩散穿过胎盘这个概念提出了质疑,也确认了11β-HSD是皮质醇母婴转移的主要"屏障"。

原始出处:

Laura I Stirrat.et al. Transfer and Metabolism of Cortisol by the Isolated Perfused Human Placenta.J Clin Endocrinol Metab. 2017.

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    2017-12-09 achengzhao
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    2018-05-20 smallant2015
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2063090, encodeId=55e9206309016, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Dec 09 02:55:00 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2075583, encodeId=f96f20e5583da, content=<a href='/topic/show?id=9ab08366e23' target=_blank style='color:#2F92EE;'>#胎盘灌注#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83667, encryptionId=9ab08366e23, topicName=胎盘灌注)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 26 04:55:00 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777708, encodeId=93231e7770860, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun May 20 23:55:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1277806, encodeId=52cd12e7806bd, content=<a href='/topic/show?id=e9f2e2180ef' target=_blank style='color:#2F92EE;'>#皮质醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72180, encryptionId=e9f2e2180ef, topicName=皮质醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c279140, createdName=vividelife, createdTime=Wed Nov 22 11:55:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406840, encodeId=858c140684090, content=<a href='/topic/show?id=2aca8365e2c' target=_blank style='color:#2F92EE;'>#胎盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83657, encryptionId=2aca8365e2c, topicName=胎盘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTItxfbnwF4Yku2j227me6wl2EGarBoTicR3tHxrMtib5tnyyEEsgxlHkk8JAS4ZjHsEF7PxhBwh1QwQ/132, createdBy=c8162575557, createdName=liuyong2981, createdTime=Wed Nov 22 11:55:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262928, encodeId=098b2629286c, content=签到学习了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Mon Nov 20 22:36:19 CST 2017, time=2017-11-20, status=1, ipAttribution=)]
    2017-11-20 Chongyang Zhang

    签到学习了很多

    0

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