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Eur Spine J:短反转时间反转恢复MRI可预判骨质疏松骨折椎体预后

2015-01-29 王海强 丁香园

胸腰段骨质疏松椎体骨折可引起剧烈背痛和后继后凸,不愈合和迟发性瘫痪,影响高龄患者的生活质量,甚至致死率增高。预测不愈合情况可帮助筛选出骨质疏松椎体骨折患者并加以防治。 近年来,MRI在诊断椎体骨折方面的重要性日益明显,但MRI预测骨质疏松椎体骨折进展的研究较少。在这方面,有学者报道短反转时间反转恢复MRI(STIR MRI)确定出28例骨质疏松椎体骨折中,普通影像检查未发现的8例骨折。亦

胸腰段骨质疏松椎体骨折可引起剧烈背痛和后继后凸,不愈合和迟发性瘫痪,影响高龄患者的生活质量,甚至致死率增高。预测不愈合情况可帮助筛选出骨质疏松椎体骨折患者并加以防治。

近年来,MRI在诊断椎体骨折方面的重要性日益明显,但MRI预测骨质疏松椎体骨折进展的研究较少。在这方面,有学者报道短反转时间反转恢复MRI(STIR MRI)确定出28例骨质疏松椎体骨折中,普通影像检查未发现的8例骨折。亦有学者报道STIR MRI在椎体骨折方面灵敏度很高。

日本学者进行了一项前瞻性研究,提示新型短反转时间反转恢复MRI可预测骨质疏松椎体预后,文章于2014年12月发表在Eur Spine J上。

该研究分析了56例患者共63个椎体的胸腰段骨折(T10-L2),平均年龄77.5岁。所有患者均为60岁以上,轻微外伤,受伤30天内MRI确定椎体骨折的诊断,采用胸腰段支具固定治疗。

除常规T1相和T2相MRI外,所有患者在就诊时还行STIR MRI检查。对骨折椎体的同源性高信号进行评估,将骨折椎体分为同源性高信号组和无同源性高信号组(图1)。同时对骨折椎体线性黑色信号区域进行评估,将骨折椎体分为线性黑色信号区域组和无线性黑色信号区域组(图2)。

figure 1.jpg

图1 典型的STIR MRI图像:a 同源性高信号改变(虚线白箭头)和b 无同源性高信号改变。

figure 2.jpg

图2 典型的STIR图像:a 线性黑色信号区域(白色箭头)和b 无线性黑色信号区域。

结果显示,16个骨折椎体有同源性高信号改变,24个骨折椎体有线性黑色信号区域。16个有同源性高信号改变的骨折椎体未发展为不愈合(图3),而47个无同源性高信号改变的骨折椎体中,14个椎体为不愈合。24个有线性黑色信号区域的骨折椎体中,10个椎体不愈合(图4),39个无线性黑色信号区域的骨折椎体中4个不愈合。

图3.jpg

图3 一例78岁老年女性,a STIR MRI提示胸11新鲜压缩骨折,有同源性高信号改变。b 伤后6月随访X线片示胸11骨折愈合

图4.jpg

图4 一例82岁老年女性,a STIR MRI提示腰1新鲜压缩骨折,有线性黑色信号区域。b 伤后6月随访X线片示腰1不愈合,有裂隙。

线性黑色信号区域组的后凸进展率(平均35%)高于无线性黑色信号区域组(平均23%),背痛的视觉模拟量表(平均35mm)也明显高于无线性黑色信号区域组(平均23mm)。

以上结果显示, STIR MRI可预判骨质疏松椎体骨折的预后,包括骨愈合,后凸和背痛。STIR MRI图像上,椎体同源性高信号为椎体愈合的标志,线性黑色区域为采用胸腰段支具治疗椎体不愈合的标志,预示着后凸和背痛。对该类患者,可采用椎体成形或后凸成形术。


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    2016-01-27 doctording1

    收藏了

    0

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    2016-01-27 doctording1

    不错,赞一个

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=60282, encodeId=c91d6028243, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 00:40:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60280, encodeId=a0686028040, content=不错,赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 00:39:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=60281, encodeId=b39760281db, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 00:39:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27710, encodeId=0d0d2e710ac, content=学习了,我也追踪一组看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5071628311, createdName=wasondan, createdTime=Mon Jun 15 23:08:00 CST 2015, time=2015-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20906, encodeId=45a02090660, content=患OS这个疾病的高风险人群提供干预措施以避免不良预后和机械治疗措施, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sun Apr 12 07:45:00 CST 2015, time=2015-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699370, encodeId=4aa616993e088, content=<a href='/topic/show?id=f5821661e14' target=_blank style='color:#2F92EE;'>#Spine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16617, encryptionId=f5821661e14, topicName=Spine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba5829925263, createdName=mgqwxj, createdTime=Wed Jan 06 03:10:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980698, encodeId=3c71198069818, content=<a href='/topic/show?id=99601018e53c' target=_blank style='color:#2F92EE;'>#骨质疏松骨折#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101875, encryptionId=99601018e53c, topicName=骨质疏松骨折)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Tue Aug 04 12:10:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16502, encodeId=10461650204, content=?学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Thu Feb 19 21:28:00 CST 2015, time=2015-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366825, encodeId=ffa51366825aa, content=<a href='/topic/show?id=708a6283509' target=_blank style='color:#2F92EE;'>#椎体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62835, encryptionId=708a6283509, topicName=椎体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Jan 31 02:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592287, encodeId=81ed159228e1e, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sat Jan 31 02:10:00 CST 2015, time=2015-01-31, status=1, ipAttribution=)]
    2016-01-27 doctording1

    非常实用

    0

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    2015-06-15 wasondan

    学习了,我也追踪一组看看

    0

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    2015-04-12 x35042875

    患OS这个疾病的高风险人群提供干预措施以避免不良预后和机械治疗措施

    0

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    2016-01-06 mgqwxj
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    2015-02-19 orthoW

    ?学习了

    0

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    2015-01-31 dingxiaobo
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    2015-01-31 Eleven17

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