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Clin Implant Dent Relat Res:不同血糖控制水平的患者种植体周临床参数与AGEs的水平相关

2018-01-30 MedSci MedSci原创

既往研究已经证实较差的血糖控制和种植体周围炎之间存在密切关系。据推测,2型糖尿病患者的血糖水平升高,种植体周龈沟液(PISF)中晚期糖基化终末产物(AGEs)的水平更高。本研究中,我们检查了糖尿病患者不同血糖水平的临床和影像学种植体周围参数和AGE水平,并评估了AGEs水平是否与临床种植体参数相关。 将参与本研究的93名患者分为四组,组1:HbA1c 6.1%-8%;第2组:HbA1c 8.1%-

既往研究已经证实较差的血糖控制和种植体周围炎之间存在密切关系。据推测,2型糖尿病患者的血糖水平升高,种植体周龈沟液(PISF)中晚期糖基化终末产物(AGEs)的水平更高。本研究中,我们检查了糖尿病患者不同血糖水平的临床和影像学种植体周围参数和AGE水平,并评估了AGEs水平是否与临床种植体参数相关。

将参与本研究的93名患者分为四组,组1:HbA1c 6.1%-8%;第2组:HbA1c 8.1%-10%;第3组:HbA1c> 10%;组4:HbA1c <6%的非糖尿病个体。记录种植体周围斑块指数(PI),探诊时出血(BOP),探诊深度(PD)和骨丧失(CBL)。使用酶联免疫吸附测定法定量PISF中的AGEs的水平。用Kruskal-Wallis检验和Pearson相关系数验证AGE水平与种植体周围参数的相关性。

结果显示,与非糖尿病患者相比,种植体周围PI、BOP、PD和CBL在组-1,-2和-3中明显更高(P <0.05)。这些参数在组2和组3中明显高于组1(P <0.01)。平均PI、BOP、PD和CBL在组2和组3中相当(P> 0.05)。PISF中AGEs的平均水平明显较高,与较高的HbA1c水平相关。AGEs与PD(P = 0.0221)和CBL(P = 0.0425)呈显着正相关,与PI水平呈明显负相关关系(P = 0.0376),HbA1c水平> 10%。

综上所述,该研究结果表明,在高血糖水平的患者中,临床和影像学的种植体参数较差,且AGEs的水平明显较高。这些发现表明,AGEs可能被认为是糖尿病患者种植体周围炎炎症的潜在标志物。

原始出处:

Al-Sowygh ZH, Ghani SMA, et al., Peri-implant conditions and levels of advanced glycation end products among patients with different glycemic control. Clin Implant Dent Relat Res. 2018 Jan 19. doi: 10.1111/cid.12584. 

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    2018-04-06 xuyu
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    2018-06-20 xuyong536
  4. [GetPortalCommentsPageByObjectIdResponse(id=1789165, encodeId=4e601e89165f1, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Fri Apr 06 04:24:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956543, encodeId=fabf1956543da, content=<a href='/topic/show?id=9559e976b0' target=_blank style='color:#2F92EE;'>#GES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7976, encryptionId=9559e976b0, topicName=GES)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Aug 12 04:24:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773193, encodeId=b9931e7319356, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Wed Jun 20 00:24:00 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701900, encodeId=34511e01900e4, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Mar 11 03:24:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284994, encodeId=c93628499420, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Feb 04 09:41:58 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284387, encodeId=f45a28438ef2, content=不同血糖控制水平的患者., beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Feb 02 07:19:49 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272983, encodeId=7b4612e29835c, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343751, encodeId=f20a1343e51ae, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446559, encodeId=d7dd1446559f8, content=<a href='/topic/show?id=dbc020961c' target=_blank style='color:#2F92EE;'>#AGEs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2096, encryptionId=dbc020961c, topicName=AGEs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=298b5239347, createdName=clmlylxy, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=)]
    2018-03-11 huangdf
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    2018-02-04 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-02-02 jyzxjiangqin

    不同血糖控制水平的患者.

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1789165, encodeId=4e601e89165f1, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Fri Apr 06 04:24:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956543, encodeId=fabf1956543da, content=<a href='/topic/show?id=9559e976b0' target=_blank style='color:#2F92EE;'>#GES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7976, encryptionId=9559e976b0, topicName=GES)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Aug 12 04:24:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773193, encodeId=b9931e7319356, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Wed Jun 20 00:24:00 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701900, encodeId=34511e01900e4, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Mar 11 03:24:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284994, encodeId=c93628499420, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Feb 04 09:41:58 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284387, encodeId=f45a28438ef2, content=不同血糖控制水平的患者., beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Feb 02 07:19:49 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272983, encodeId=7b4612e29835c, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343751, encodeId=f20a1343e51ae, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446559, encodeId=d7dd1446559f8, content=<a href='/topic/show?id=dbc020961c' target=_blank style='color:#2F92EE;'>#AGEs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2096, encryptionId=dbc020961c, topicName=AGEs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=298b5239347, createdName=clmlylxy, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1789165, encodeId=4e601e89165f1, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Fri Apr 06 04:24:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956543, encodeId=fabf1956543da, content=<a href='/topic/show?id=9559e976b0' target=_blank style='color:#2F92EE;'>#GES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7976, encryptionId=9559e976b0, topicName=GES)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sun Aug 12 04:24:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773193, encodeId=b9931e7319356, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Wed Jun 20 00:24:00 CST 2018, time=2018-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701900, encodeId=34511e01900e4, content=<a href='/topic/show?id=04b9e4784aa' target=_blank style='color:#2F92EE;'>#种植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74784, encryptionId=04b9e4784aa, topicName=种植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e130405619, createdName=huangdf, createdTime=Sun Mar 11 03:24:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284994, encodeId=c93628499420, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Feb 04 09:41:58 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284387, encodeId=f45a28438ef2, content=不同血糖控制水平的患者., beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Feb 02 07:19:49 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272983, encodeId=7b4612e29835c, content=<a href='/topic/show?id=2f468983351' target=_blank style='color:#2F92EE;'>#血糖控制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89833, encryptionId=2f468983351, topicName=血糖控制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef84111, createdName=whlxd, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343751, encodeId=f20a1343e51ae, content=<a href='/topic/show?id=d512e47853f' target=_blank style='color:#2F92EE;'>#种植体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74785, encryptionId=d512e47853f, topicName=种植体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TnzXXl41yf6V8fHrDb5JdtxOgpaY6vplUhHtL8BzDh1xMtcap9H1IOlE8umxPGovhIuVkeGTY26eNUFCFaOheQ/132, createdBy=29702500197, createdName=ms6279672939590805, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446559, encodeId=d7dd1446559f8, content=<a href='/topic/show?id=dbc020961c' target=_blank style='color:#2F92EE;'>#AGEs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2096, encryptionId=dbc020961c, topicName=AGEs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=298b5239347, createdName=clmlylxy, createdTime=Thu Feb 01 05:24:00 CST 2018, time=2018-02-01, status=1, ipAttribution=)]
    2018-02-01 clmlylxy
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