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IBD: 二手烟会增加克罗恩氏病患者肠道手术的风险

2020-07-16 MedSci原创 MedSci原创

尽管有大量证据表明主动吸烟会带来负面影响,但被动吸烟对克罗恩病(CD)病程的影响仍不清楚。本项研究的目的是评估被动吸烟是否是CD肠道手术的危险因素。

背景

尽管有大量证据表明主动吸烟会带来负面影响,但被动吸烟对克罗恩病(CD)病程的影响仍不清楚。本项研究的目的是评估被动吸烟是否是CD肠道手术的危险因素。

 

方法

这项研究是对563例CD患者进行的一项病例对照研究。对接受被动和主动吸烟的患者进行了结构化访谈。对于临床数据,进行了图表检查。回应率为84%,尚待分析471例。为了评估主要目标,即暴露于被动吸烟对肠道手术风险的影响,仅纳入从未主动吸烟的患者。

 

结果

在169例从不主动吸烟的患者中,有91例(54%)暴露于被动吸烟。暴露的患者比未暴露的患者更有可能接受肠道手术(67%vs 30%;P <0.001)。多变量Cox回归分析显示,被动吸烟是肠道手术诊断后的回肠疾病调整后的独立危险因素(危险比,1.7; 95%CI,1.04-2.9;P = 0.034)和在诊断时加强或穿透行为(危险比,1.9; 95%CI,1.2–3.1;P = 0.01)。儿童时期的被动吸烟是晚年成为主动吸烟者的危险因素(优势比为2.2; 95%CI为1.5-3.2;P <0.001)。

 

结论

被动吸烟会增加CD患者肠道手术的风险。

 

原始出处:

Susanna Scharrer. Et al. Passive Smoking Increases the Risk for Intestinal Surgeries in Patients With Crohn’s Disease. Inflammatory Bowel Diseases.2020.

 

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