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Sci Rep:循环内皮祖细胞水平升高与脑出血患者良好功能预后相关

2016-07-11 phylis 译 MedSci原创

循环内皮祖细胞(EPCs)在损伤脑组织再生中发挥作用。然而,循环EPC水平与脑出血(ICH)功能恢复的关系尚未研究。因此,研究者旨在研究循环内皮祖细胞脑出血预后的影响。406例发病在12 小时内的原发性脑出血(男,71.7%岁,10.8年;72.7 ± )纳入前瞻性研究。。主要预后变量是12个月良好功能结局(改良Rankin量表≤2),6个月残余量作为辅助变量。通过流式细胞仪检测,入院,72h及7

循环内皮祖细胞(EPCs)在损伤脑组织再生中发挥作用。然而,循环EPC水平与脑出血(ICH)功能恢复的关系尚未研究。因此,研究者旨在研究循环内皮祖细胞脑出血预后的影响。

406例发病在12 小时内的原发性脑出血(男,71.7%岁,10.8年;72.7 ± )纳入前瞻性研究。。主要预后变量是12个月良好功能结局(改良Rankin量表≤2),6个月残余量作为辅助变量。通过流式细胞仪检测,入院,72h及7d的循环内皮祖细胞(CD34(+)/ CD133(+)/ KDR(+))的水平。研究结果表明,预后良好的患者表现出72 小时和7天EPC数较高。然而,校正年龄,基线卒中严重程度和出血量后,只有7天的EPC水平与12个月良好功能预后独立相关(OR 1.15;95%CI,1.01-1.35)。此外,7天的EPC水平与残余量呈负相关(r = -0.525)。

总之,这些结果表明,内皮祖细胞可能在脑出血患者功能恢复的作用。

原始出处:

Pías-Peleteiro J, Pérez-Mato M, et al. Increased Endothelial Progenitor Cell Levels are Associated with Good Outcome in Intracerebral Hemorrhage. Sci Rep. 2016 Jun 27


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    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

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