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Lancet Infect Dis:脊髓灰质炎病毒灭活疫苗制备的全球介绍

2015-08-17 崔倩 译 MedSci原创

    使用灭活脊髓灰质炎病毒疫苗(IPV)的国家的安全数据对于全球根除脊髓灰质炎战略,以引进IPV到所有国家的免疫计划中是非常重要的。在美国,自1997年以来IPV已被列入常规免疫计划,该研究的目的是分析IPV管理报告给美国疫苗不良事件报告系统(VAERS)后的不良事件。    研究人员分析了2000年1月1日和2012年12月31日之间提交的与IPV相关

使用灭活脊髓灰质炎病毒疫苗(IPV)的国家的安全数据对于全球根除脊髓灰质炎战略,以引进IPV到所有国家的免疫计划中是非常重要的。在美国,自1997年以来IPV已被列入常规免疫计划,该研究的目的是分析IPV管理报告给美国疫苗不良事件报告系统(VAERS)后的不良事件。

研究人员分析了2000年1月1日和2012年12月31日之间提交的与IPV相关的所有VAERS数据,无论是作为个人还是作为联合疫苗,所有年龄和性别组都包括在内。研究人员分析了个别报告的数量和事件类型(非严重,非致死严重的和死亡报告),并探讨了最常用的编码事件的术语来描述不良事件。研究人员根据此前公布的身体系统类别(呼吸、心血管、神经系统、胃肠道、其他感染、以及其他非传染性)和审查报告的死亡,以确定死因。考虑对之前接种疫苗后发生婴儿综合征的事件,研究人员将婴儿猝死综合症作为一个独立的死亡原因。研究人员使用bao,以确定与其他疫苗相比IPV不成比例的不良事件的报告。研究人员对1991〜2000年其他VAERS数据进行了分析,比较了IPV和口服脊髓灰质炎疫苗(OPV)的安全性。

在提交的41792例不良事件报告中,39568例(95%)为7岁以下的儿童。在这个儿童年龄组中有38381名(97%)儿童报告同时进行接种IPV和其他疫苗(最常见的肺炎球菌和无细胞百日咳疫苗),而独立接种IPV疫苗的儿童占所有报告的0.5%。34880例报告为非严重事件(88%),3905例报告为非致命性严重事件(10%),783例报告是死亡报告(2%)。注射部位红斑是最常见用于非严重事件的编码术语(29%),以及非致命的严重事件发热(38%)。大多数死亡(96%)是年龄在12个月或更小的孩子;大多数(52%)的报告原因为婴儿猝死综合症死亡。联合IPV和全细胞百日咳疫苗,OPV和全细胞百日咳疫苗,以及OPV和非细胞百日咳疫苗的安全配置结果是相似的。研究人员注意到,在1990年和2013年之间与其他疫苗相比,没有迹象显示接种IPV疫苗后的不良反应事件的报告有不成比例现象。

在2000年和2012年之间超过2.5亿IPV剂量的分布出现了相当一部分的不良事件的报告。IPV后婴儿猝死综合征的报道与其他疫苗的报道模式是一致的。IPV接种后不良事件的报告中,没有出现新的或意外的致命的、非致命性严重、不严重的报告。

原始出处:

Dr Shahed Iqbal, PhD et al.Preparation for global introduction of inactivated poliovirus vaccine,Lancet Infectious Diseases,2015.8.16

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    2016-01-12 howi
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    2015-08-17 stupidox

    不良事件中死亡跟疫苗到底啥关系咋不说清楚

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