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Am J Clin Nutr: 摄入过多的胆固醇和鸡蛋会增加绝经后妇女发生的心血管疾病的发生率

2021-04-16 MedSci原创 MedSci原创

膳食胆固醇对心血管的潜在影响已经被争论了数十年,虽然有随机实验证实增加饮食中胆固醇的摄入量可能会增加血清低密度脂蛋白胆固醇的含量。

      膳食胆固醇血管的潜在影响已经被争论了数十年,虽然有随机实验证实增加饮食中胆固醇的摄入量可能会增加血清低密度脂蛋白胆固醇的含量,而低密度脂蛋白是动脉粥样硬化性心血管疾病(CVD)的危险因素之一,但是这样的血脂改变程度并不是很大。在日常饮食中鸡蛋是相对更为常见的高质量蛋白质和其他营养素的来源,也是主要的饮食中的胆固醇的来源。因此,本项研究旨在评估饮食中胆固醇和鸡蛋摄入量与心血管事件(CVD)以及全因和特定原因死亡率之间的关联。

 

      研究人员将96831名在美国妇女健康计划的基线研究期间且年龄在50-79岁之间,没有已知的CVD或癌症的美国绝经后妇女纳入本项研究。饮食摄入的资料是使用经过验证的数据库进行回顾性收集的。所有患者均随访至2018年2月,并确定了所有的CVD事件(即缺血性心脏病(IHD)和中风)以及所有原因和特定原因的死亡情况。

 

      研究结果显示在随访期间,总共发生了9808例CVD突发事件和19508例全因死亡事件。在对传统危险因素和关键膳食营养素进行多变量调整后,膳食胆固醇摄入量与CVD的发生之间存在中等强度的相关性(HR Q5 VS Q1:1.12; 95%CI:1.03-1.21 ;P<0.001),也与死亡率的增减存在一定相关系(HR Q5 vs Q1:1.09; 95%CI:1.02-1.15 ; P<0.001)。饮食中胆固醇与IHD发生率(P= 0.007),缺血性中风(P= 0.002)和CVD死亡率(P= 0.002)呈反比关系(P= 0.037),而与癌症,阿尔茨海默氏病,呼吸系统疾病或其他原因的死亡率却没有关联(P> 0.05)。每天吃超过一个鸡蛋还与CVD的发生风险(P= 0.004)和全因死亡率(P<0.001)较高有关。

图:鸡蛋摄入与各种疾病之间的影响

 

      本项研究证实在绝经后妇女中,较高的饮食胆固醇摄入量和较高的鸡蛋摄入量都与心血管疾病风险的增加和全因死亡率增加有关。

 

 

 

原始出处:

Guo-Chong Chen. Et al. Dietary cholesterol and egg intake in relation to incident cardiovascular disease and all-cause and cause-specific mortality in postmenopausal women. The American Journal of Clinical Nutrition.2021.

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    2021-04-19 大大大水瓜

    饮食很重要

    0

  3. 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    2021-04-19 ZJYYY7

    学习了学习了

    0

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level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Sat Apr 17 18:18:21 CST 2021, time=2021-04-17, status=1, ipAttribution=)]
    2021-04-19 ZJYYY7

    我一早上两个蛋 哈哈哈

    0

  5. 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topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Apr 18 11:42:09 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631645, encodeId=7ceb1631645cb, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sun Apr 18 11:42:09 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957873, encodeId=84e995e8738c, content=饮食很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Sat Apr 17 18:18:21 CST 2021, time=2021-04-17, status=1, ipAttribution=)]
    2021-04-19 ZJYYY7

    饮食习惯很重要

    0

  6. 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topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Apr 18 11:42:09 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631645, encodeId=7ceb1631645cb, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sun Apr 18 11:42:09 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957873, encodeId=84e995e8738c, content=饮食很重要, beContent=null, objectType=article, channel=null, 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=1826682, encodeId=784518266827a, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jul 03 18:42:09 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958491, encodeId=7afe95849143, content=饮食很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210419/f10b2302d66c46fe962e825971833a42/5ba1145dd82f45c9b219acb84255d09e.jpg, createdBy=60305482231, createdName=大大大水瓜, createdTime=Mon Apr 19 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level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Sat Apr 17 18:18:21 CST 2021, time=2021-04-17, status=1, ipAttribution=)]
  9. 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topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Apr 18 11:42:09 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631645, encodeId=7ceb1631645cb, content=<a href='/topic/show?id=6395e888343' target=_blank style='color:#2F92EE;'>#绝经后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78883, encryptionId=6395e888343, topicName=绝经后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b921798518, createdName=zxxiang, createdTime=Sun Apr 18 11:42:09 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957873, encodeId=84e995e8738c, content=饮食很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dffa5465843, createdName=ms2000001361349190, createdTime=Sat Apr 17 18:18:21 CST 2021, time=2021-04-17, status=1, ipAttribution=)]
    2021-04-18 zxxiang
  10. 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    2021-04-17 ms2000001361349190

    饮食很重要

    0

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