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Clin Gastroenterol H:丙型肝炎、糖尿病、肥胖和慢性肾脏病流行的汇合情况分析!

2017-06-04 xing.T MedSci原创

在NHANES的数据分析中,研究人员发现,慢性丙型肝炎患者主要心血管合并疾病负担较重。特别是糖尿病和慢性肾脏疾病与慢性丙型肝炎患者的大量死亡有关。

肥胖、肾脏疾病和糖尿病是一种常见的疾病,会影响慢性丙型肝炎患者的结局,近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,研究人员旨在量化慢性丙型肝炎成年人这些合并疾病的负担以及评估慢性丙型肝炎以及合并症患者的死亡风险。

研究人员通过对第三次全国健康和营养调查(NHANES III)13726参与者以及1999年至2012年期间NHANES研究的23691名参与者进行了一项横断面和前瞻性分析。研究人员采用血清样品进行了丙型肝炎病毒抗体(抗-HCV)的分析,在样品中发现是抗-HCV抗体阳性,研究人员量化了HCV RNA(病毒载量)。抗-HCV阳性并且检测到HCV RNA的个人被认为患有慢性丙型肝炎,合并疾病定义是通过自我报告、体检、实验室数据来确定。研究人员使用Logistic模型和预测利润来估计慢性丙型肝炎患者调整后的合并疾病患病率。基于慢性丙型肝炎状态,有或无合并疾病,研究人员使用泊松回归模型来估计调整后的死亡率。Cox比例风险回归模型来估计全因、心血管和癌症死亡率调整后的风险比和95%可信区间。

在慢性丙型肝炎患者中,估计的人口调整后糖尿病患病率为17.9%(95%可信区间为11.2-27.5)以及肥胖患病率为20.9%(95%可信区间为12.4-29.5)。总的来说,69.6%的慢性丙型肝炎患者至少有1个主要的心血管代谢合并疾病(95%可信区间为62.1%-76.2%)。只有38%的慢性丙型肝炎成年患者报告了肝病的诊断。慢性丙型肝炎与死亡风险显著增加相关(风险比为2.45),尤其是存在糖尿病(风险比为3.24)或慢性肾脏病(风险比为4.39)的情况下。

在NHANES的数据分析中,研究人员发现,慢性丙型肝炎患者主要心血管合并疾病负担较重。特别是糖尿病和慢性肾脏疾病与慢性丙型肝炎患者的大量死亡有关。

原始出处:

Mariana Lazo,et al. Confluence of Epidemics of Hepatitis C, Diabetes, Obesity, and Chronic Kidney Disease in the United States Population. Clinical gastroenterology and hepatology 2017. http://www.cghjournal.org/article/S1542-3565(17)30667-5/fulltext

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    2017-07-01 许安
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createdName=ylzr123, createdTime=Mon Jun 05 09:33:01 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206777, encodeId=20f1206e7744, content=文章很好,学习受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Jun 05 09:28:25 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-07 1e10c84am36(暂无匿称)

    文章很好,拜读了

    0

  5. 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createdName=ylzr123, createdTime=Mon Jun 05 09:33:01 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206777, encodeId=20f1206e7744, content=文章很好,学习受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Jun 05 09:28:25 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-06 changjiu

    学习了,谢谢分享

    0

  6. 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  7. 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createdName=ylzr123, createdTime=Mon Jun 05 09:33:01 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206777, encodeId=20f1206e7744, content=文章很好,学习受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Jun 05 09:28:25 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-05 圣艮山

    学习了不少事情

    0

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    2017-06-05 ylzr123

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。给点个赞!

    0

  10. 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createdName=ylzr123, createdTime=Mon Jun 05 09:33:01 CST 2017, time=2017-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=206777, encodeId=20f1206e7744, content=文章很好,学习受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Jun 05 09:28:25 CST 2017, time=2017-06-05, status=1, ipAttribution=)]
    2017-06-05 1e10c84am36(暂无匿称)

    文章很好,学习受益

    0

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