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CLIN CANCER RES：GABBR2可以作为EGFR19缺失肺腺癌的治疗靶点

2017-09-05 MedSci MedSci原创

肺腺癌EGFR19GABBR2
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过去的几十年中，人们见证了 个体化靶向治疗肺癌的快速进展。但是EGFR突变肺癌对TKI治疗的反应是否涉及到遗传学改变尚不清楚。CLIN CANCER RES近期发表了一篇文章，研究了这个问题。

过去的几十年中，人们见证了 个体化靶向治疗肺癌的快速进展。但是EGFR突变肺癌对TKI治疗的反应是否涉及到遗传学改变尚不清楚。CLIN CANCER RES近期发表了一篇文章，研究了这个问题。

作者检测了出现部分反应的EGFR19缺失的Ⅲa期肺腺癌患者在接受厄洛替尼治疗前和治疗后42天的肿瘤组织标本。针对上调或下调的潜在靶点基因进行研究，以期阐明厄洛替尼治疗反应的调节机制。研究结果证实了两个异常的甲基化基因CBFAT2T3和GABBR2起到的作用。GABBR2基因exon2和exon3之间的差异性甲基化区域在患者中得到确认。在EGFR19缺失的细胞系HCC4006和HCC827中，GABBR2显着下调，但是在厄洛替尼治疗后的EGFR野生型A549细胞中保持不变。在HCC827细胞中，GABBR2表达上调显着改善厄洛替尼诱导的细胞凋亡。GABBR2显着下调时同时观察到S6，p-p70 S6以及p-ERK1/2减少，表明GABBR2通过 ERK1/2通路在EGFR信号传导中起到了重要作用。

文章最后认为，GABBR2基因可以作为EGFR19缺失的Ⅲa期肺腺癌厄洛替尼诱导治疗后的潜在基因治疗靶点。

原始出处：

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    2018-01-20 Yahaha

    谢谢分享

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=280482, encodeId=fc77280482f7, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/8F614D4C7782A43FC285DED9FF682889/100, createdBy=b4a62141201, createdName=Yahaha, createdTime=Sat Jan 20 22:24:24 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895343, encodeId=44be18953432d, content=<a href='/topic/show?id=18ae64e21d3' target=_blank style='color:#2F92EE;'>#治疗靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64721, encryptionId=18ae64e21d3, topicName=治疗靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Thu Oct 05 00:39:00 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1534332, encodeId=354c153433225, content=<a href='/topic/show?id=22b3e9887e' target=_blank style='color:#2F92EE;'>#GFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7988, encryptionId=22b3e9887e, topicName=GFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0a812532020, createdName=liuyiping, createdTime=Thu Sep 07 04:39:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240875, encodeId=38a82408e54f, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Sep 05 23:56:53 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240833, encodeId=791a240833c9, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Tue Sep 05 22:46:28 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240766, encodeId=6ef9240e663c, content=学习了.TKI的机制又更清楚了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83eo1pakLFUEWD4aw9tDzG7UDuyJKicLYyJtiaVNfiaY3JfcSoCYagoEiaoq6eh09qnrgoGCZQqfl5eo1KQ/0, createdBy=fed0100583, createdName=vicjaychou, createdTime=Tue Sep 05 15:25:32 CST 2017, time=2017-09-05, status=1, ipAttribution=)]
    2017-10-05 drj2003

    #治疗靶点#

    0

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    2017-09-07 liuyiping

    #GFR#

    0

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    2017-09-05 忠诚向上

    好好看下.内容丰富

    0

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    2017-09-05 luominglian113

    学习了谢谢分享

    0

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    2017-09-05 vicjaychou

    学习了.TKI的机制又更清楚了

    0

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