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Lancet Diab & Endo:糖尿病防控能够降低肺结核发病及死亡风险

2015-03-09 姜英浩译 MedSci原创

糖尿病的发生能够提升肺结核发病的风险,也会提升结核患者治疗时副作用出现的风险。目前,在许多低、中等收入国家,其肺结核的发病率居高不下,同时,糖尿病的发病在这些国家也开始日益增加。因此,从全世界的范围来看,预防糖尿病有可能成为促进肺结核防控的一项新举措。 在2015年3月6日的the Lancet Diabetes & Endocrinology杂志上在线发表了一项最新研究成果,来自台湾流

糖尿病的发生能够提升肺结核发病的风险,也会提升结核患者治疗时副作用出现的风险。目前,在许多低、中等收入国家,其肺结核的发病率居高不下,同时,糖尿病的发病在这些国家也开始日益增加。因此,从全世界的范围来看,预防糖尿病有可能成为促进肺结核防控的一项新举措。

在2015年3月6日的the Lancet Diabetes & Endocrinology杂志上在线发表了一项最新研究成果,来自台湾流行病与预防医学研究所的Hsien-Ho Lin医生带领的研究团队利用动态的肺结核传播模型分析了13个结核高负担国家的糖尿病发病情况对肺结核流行病学的潜在影响。研究人员利用了每个国家之前糖尿病流行情况的数据,构建了未来糖尿病可能流行范围的模拟情节。将这些国家特异的模型进行校准,估测肺结核发病的倾向。随后他们预测到,通过糖尿病预防的方案能够降低肺结核的负担。

结果表明,在这13个国家中,如果糖尿病的发病率仍像过去的十年这样增长的话(基础情况),到2035年,肺结核发病率的累积降低将达到8.8 %(95% CI 4.0–15.8),死亡率将为34.0 %(30.3-39.6)。如果将糖尿病的发病率的绝对值降低6.6-13.8 %,能够促进肺结核发病的绝对值降低达到11.5-25.2 %,死亡率降低至8.7-19.4 %。与基础情况相比,阻止糖尿病发病率的上升将在20年内减少13个国家6.0 百万(95 %CI 5.1-6.9)的肺结核病例,以及1.1 百万(1.0-1.3)的死亡人数。如果对糖尿病的控制有效,到2025年能够降低其35 %的发病率的话,那么至2035年,将会总共避免7.8百万(6.7-9.0)的肺结核病例以及1.5百万(1.3-1.7)的死亡人数。

因此,在肺结核高负担国家里,糖尿病的流行能够对肺结核的流行病学情况产生持续的影响。从本研究中的糖尿病与肺结核之间构建的这样的关系给我们提供了一条新的思路,传统的传染病与非传染病之间的界限可能需要被打破重建了。

原始出处:

Pan SC1, Ku CC2, Kao D3, Ezzati M4, Fang CT5, Lin HH6.Effect of diabetes on tuberculosis control in 13 countries with high tuberculosis: a modelling study.Lancet Diabetes Endocrinol. 2015 Mar 5. pii: S2213-8587(15)00042-X. doi: 10.1016/S2213-8587(15)00042-X. [Epub ahead of print]

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1637052, encodeId=bc62163e05244, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri May 29 13:47:00 CST 2015, time=2015-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27132, encodeId=db312e1320e, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Thu Jun 11 18:50:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828026, encodeId=e53718280266b, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Feb 07 08:47:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20353, encodeId=e24a2035363, content=AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 22:42:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253948, encodeId=9715125394836, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Wed Mar 11 00:47:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255509, encodeId=e9b4125550985, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Mar 11 00:47:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
    2015-06-11 ljjj1053

    好好学习一下

    0

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    2016-02-07 howi
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    2015-04-11 x35042875

    AKI对心衰临床治疗意义重大,但依然需要研究检验其适用性

    0

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