BMC Endocr Disord：转移部位对神经内分泌肿瘤（NEN）患者生存的影响

2020-04-23 MedSci原创 MedSci原创

神经内分泌肿瘤（NENs）根据肿瘤的起源和级别表现出不同的行为。我们假设肿瘤起源和转移部位可能在生存中起到一定的作用。

神经内分泌肿瘤（NENs）根据肿瘤的起源和级别表现出不同的行为。我们假设肿瘤起源和转移部位可能在生存中起到一定的作用。

我们查询了SEER数据库（2010-2014年）中确诊为NENs并记录了转移部位的患者，确定了2005例患者。通过Kaplan-Meier方法估计各时间点的总体生存（OS），并使用Cox比例危害模型评估了相关变量与OS的关系。

结果显示，肺、肝、骨和脑转移患者中分别有9、77、7和6%的转移患者发生肺、肝、骨和脑转移。在多变量模型中，转移位置与较差的生存率显著相关（肝HR：1.677（1.226-2.294）；（骨转移HR：1.412（0.965-2.065）；脑HR：1.666（1.177-2.357））。我们根据原发部位、转移部位、转移位置、年龄、性别、组织学和肿瘤大小制作了一套评分系统，可以将转移性NEN患者分为低危、中危和高危三类，帮助医生进行决策。

综上所述，该研究结果表明，转移部位在转移性NEN患者的生存中起着重要作用，而与通常描述的预后因素无关，应在生存估计中予以考虑。

原始出处：

Nikolaos A. Trikalinos, et al., Effect of metastatic site on survival in patients with neuroendocrine neoplasms (NENs). An analysis of SEER data from 2010 to 2014. BMC Endocr Disord. 2020; 20: 44. doi: 10.1186/s12902-020-0525-6

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2020-10-13 lily1616

#神经内分泌#

64 0
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2020-05-09 一叶知秋

#分泌#

71 0
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2021-01-26 1249898am27暂无昵称

#内分泌肿瘤#

94 0
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2021-02-02 tastas

#患者生存#

72 0
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2021-01-23 cmsvly

#Disord#

56 0
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2021-02-13 cmj8wellington

#Dis#

56 0
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2021-02-09 ms3025846204744509

#BMC#

53 0

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