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Biochem Biophys Res Commun:在眼睛发育过程中DTNKS通过激活JNK信号调节细胞凋亡

2018-07-02 cuiguizhong MedSci原创

温州医科大学眼科与视光学院眼科医院的Feng Y和Li Z等近日在Biochem Biophys Res Commun发表了一项研究,他们以果蝇为研究模型,研究DTNKS在眼睛发育过程中是否具有诱导凋亡的作用。

温州医科大学眼科与视光学院眼科医院的Feng Y和Li Z等近日在Biochem Biophys Res Commun发表了一项研究,他们以果蝇为研究模型,研究DTNKS在眼睛发育过程中是否具有诱导凋亡的作用。

在各种细胞和发育过程中,程序性细胞死亡(PCD)或细胞凋亡都具有重要作用,细胞凋亡的紊乱导致许多疾病。因此,细胞凋亡的调节过程非常重要。果蝇里的坦科聚合酶(DTNKS)是一种进化上保守的、有(ADP-核糖)聚合酶活性的蛋白质。据报道,在哺乳动物细胞中,坦科聚合酶(TNKSs)参与调节细胞死亡。为了确定DTNKS在体内发育中是否具有诱导凋亡的作用,他们使用果蝇作为模型系统,构建表达DTNKS的转基因苍蝇。

他们表明DTNKS的异位表达促进半胱氨酸蛋白酶依赖的细胞凋亡。通过RNAi敲除DTNKS,在眼睛发育过程中,可以显着缓解由细胞凋亡蛋白前体积累、异位表达引起的凋亡缺陷。此外,他们的结果显示,DTNKS的异位表达导致c-Jun N端激酶(JNK)信号的激活,这可能是DTNKS介导的细胞凋亡所必需的。

综上所述,他们的发现确定了DTNKS通过激活果蝇中的JNK信号途径来调节细胞凋亡的作用机制。

原文出处:

Feng, Y., et al., Tankyrase regulates apoptosis by activating JNK signaling in Drosophila. Biochem Biophys Res Commun, 2018.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 

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    2018-11-12 liuli5079
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    2019-06-03 Tamikia
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    2019-05-01 sunylz
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2087374, encodeId=7b80208e3747d, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Mon Nov 12 18:00:00 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1707551, encodeId=b7461e07551b3, content=<a href='/topic/show?id=9f7c99e256' target=_blank style='color:#2F92EE;'>#IOP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9972, encryptionId=9f7c99e256, topicName=IOP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bb031431834, createdName=124987c6m46暂无昵称, createdTime=Wed Jul 25 23:00:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784811, encodeId=f3a81e8481116, content=<a href='/topic/show?id=b70063037a' target=_blank style='color:#2F92EE;'>#DTNKS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6303, encryptionId=b70063037a, topicName=DTNKS)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Jr8S1dfvNyP22t32IFDXJXnpd5AGlDibiajL5cl3pxj7OPCeAeibLhzOmZn5Q2Oicc6uKOCnxGNOggdLtI3hIW7huQ/132, createdBy=66e52500008, createdName=Tamikia, createdTime=Mon Jun 03 20:00:00 CST 2019, time=2019-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918177, encodeId=2ec919181e744, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed May 01 07:00:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1340278, encodeId=aa7f13402e8d5, content=<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/EFCEF19303EB52B3F41B30C45995AF2C/100, createdBy=8e712500159, createdName=ms8538335253054589, createdTime=Wed Jul 04 14:00:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347314, encodeId=f111134e31498, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Wed Jul 04 14:00:00 CST 2018, time=2018-07-04, status=1, ipAttribution=)]
    2018-07-04 neurowu
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