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韩国首次运用血清疗法成功治愈两名新冠重症患者,一名已出院

2020-04-09 南博一 澎湃新闻

近日,韩国两名新冠肺炎重症患者在接受痊愈者血清治疗后康复,首次验证了血清治疗的效果。

近日,韩国两名新冠肺炎重症患者在接受痊愈者血清治疗后康复,首次验证了血清治疗的效果。

据韩国《中央日报》4月8日报道,韩国Severance医院感染内科崔俊勇(音译)教授团队4月7日表示,在对国内两名新冠肺炎重症患者注射痊愈者的血清后,患者的症状已有好转,目前两人均已治愈,其中一人已经出院。对两名患者的研究结果刊载在最新一期《大韩医学会报》(Journal of Korean Medical Science)上。

在接受血清治疗的两名患者中,71岁的金某曾使用抗疟疾和抗艾滋药物进行抗病毒治疗,但病情始终没有好转。此后患者被转移到Severance医院进行重症治疗,使用呼吸机后仍未缓解呼吸困难症状。

于是,研究团队使用已经痊愈并度过两周隔离期的某男性患者提供的恢复期血清,先后分两次,间隔12小时为金某注射了共500毫升,并同时进行类固醇治疗。接受血清治疗和类固醇治疗后,金某开始退烧,胸部X光片也显示,金某左右两肺没有继续病变,也没有表现出特别的副作用。现在,金某已经摘下呼吸机,检测结果为阴性,宣布痊愈。

第二例接受血浆治疗的患者为67岁的李某,患有高血压。从确诊的第三天开始,李某出现呼吸困难症状,吸氧量大幅增加,左肺严重病变,被转移到Severance医院治疗。转入医院后,李某出现免疫系统疾病(淋巴细胞减少症)和严重呼吸困难,不得不使用呼吸机。医生对李某也使用了抗疟疾和抗艾滋治疗药物,并尝试翻转其身体以提高血氧饱和度,但患者仍持续出现淋巴细胞减少和高烧症状,即使在进行类固醇治疗后,淋巴细胞减少症也没有缓解。

研究团队同样先后两次,间隔12小时给李某注射了痊愈患者恢复期的血清,并同时对李某进行类固醇治疗。此后,李某的淋巴细胞数量开始恢复。胸部X光片显示,李某肺部状态已经大幅好转。此后李某被宣告痊愈,并在3月末顺利出院。

崔俊勇教授表示,“恢复期血清中含有中和抗体,可以遏制病毒增殖,在治疗新冠肺炎重症患者时,可以尝试配合其他疗法同时使用。”

此外,崔教授还表示,“血清治疗有一定的副作用,且没有经过大规模临床试验,没有充足的科学证据证明其有效,但对于抗病毒治疗已经不起作用的重症患者,可以考虑搭配类固醇治疗一起进行”。

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    2020-04-09 公卫新人

    新冠肺炎,疫情何时才能消失

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