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衰老基因研究研究汇萃(附MedSci点评)

2011-11-06 MedSci原创 MedSci原创

 MedSci点评:  衰老是永恒的热点,无论是基础医学还是临床研究,但研究起来是一波三折。早年通过低等生物(线虫)发现Sirt家族成员与衰老有关,包括Sirt 1-6家族成员。进一步在哺乳动物中,也有类似发现,如在小鼠中发现SIRT1具有抗衰老功能。 为了进一步研究衰老机制,人类通过快速衰老的小鼠模型——SAMP8(senescence-accelerated m

 MedSci点评:  衰老是永恒的热点,无论是基础医学还是临床研究,但研究起来是一波三折。早年通过低等生物(线虫)发现Sirt家族成员与衰老有关,包括Sirt 1-6家族成员。进一步在哺乳动物中,也有类似发现,如在小鼠中发现SIRT1具有抗衰老功能。 为了进一步研究衰老机制,人类通过快速衰老的小鼠模型——SAMP8(senescence-accelerated mouse prone/8)进一步研究衰老的机制,获得了不少新的进展,尤其是学习记忆,老年性痴呆的研究。 但是遗憾的是最近宣布,针对SIRT1基因的抗衰老药物被证明无效,给人类抗衰老的研究蒙上阴影。2010年又发现TERC基因可能与衰老有关,相关研究正在更深入进行。另外,针对基因组学和蛋白质组学的抗衰老研究同样如火如荼,但是人类对衰老的研究始终不会停止。 而最新在代谢研究中又发现Prx1基因可能与衰老有关。因为先前已经证实,低热量饮食习惯可以长寿,这目前基本是科学定论,因此,能降低代谢水平的基因,有可能是抗衰老的的靶标。 下面总结相关的研究以享读者,MedSci将不断提供高质量评论,帮助大家梳理思路。 Mo

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  1. [GetPortalCommentsPageByObjectIdResponse(id=5542, encodeId=3be05542d7, content=虽然有点局部,但将自由基与饮食相结合起来解释,也是比较好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb4079637, createdName=aj2013, createdTime=Thu Mar 28 10:16:00 CST 2013, time=2013-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3616, encodeId=85a4361665, content=楼上,你就催吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=221.11.61.210, createdTime=Tue Nov 08 17:19:00 CST 2011, time=2011-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605622, encodeId=4d6616056220e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Nov 07 15:51:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3600, encodeId=395b3600f6, content=medsci评论真精彩,不愧是有水平的公司, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 06 01:24:00 CST 2011, time=2011-11-06, status=1, ipAttribution=)]
    2013-03-28 aj2013

    虽然有点局部,但将自由基与饮食相结合起来解释,也是比较好的

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=5542, encodeId=3be05542d7, content=虽然有点局部,但将自由基与饮食相结合起来解释,也是比较好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb4079637, createdName=aj2013, createdTime=Thu Mar 28 10:16:00 CST 2013, time=2013-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3616, encodeId=85a4361665, content=楼上,你就催吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=221.11.61.210, createdTime=Tue Nov 08 17:19:00 CST 2011, time=2011-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605622, encodeId=4d6616056220e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Nov 07 15:51:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3600, encodeId=395b3600f6, content=medsci评论真精彩,不愧是有水平的公司, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 06 01:24:00 CST 2011, time=2011-11-06, status=1, ipAttribution=)]
    2011-11-08 221.11.61.210

    楼上,你就催吧

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=5542, encodeId=3be05542d7, content=虽然有点局部,但将自由基与饮食相结合起来解释,也是比较好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb4079637, createdName=aj2013, createdTime=Thu Mar 28 10:16:00 CST 2013, time=2013-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3616, encodeId=85a4361665, content=楼上,你就催吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=221.11.61.210, createdTime=Tue Nov 08 17:19:00 CST 2011, time=2011-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605622, encodeId=4d6616056220e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Nov 07 15:51:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3600, encodeId=395b3600f6, content=medsci评论真精彩,不愧是有水平的公司, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 06 01:24:00 CST 2011, time=2011-11-06, status=1, ipAttribution=)]
    2011-11-07 爆笑小医
  4. [GetPortalCommentsPageByObjectIdResponse(id=5542, encodeId=3be05542d7, content=虽然有点局部,但将自由基与饮食相结合起来解释,也是比较好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=210, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fb4079637, createdName=aj2013, createdTime=Thu Mar 28 10:16:00 CST 2013, time=2013-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3616, encodeId=85a4361665, content=楼上,你就催吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=221.11.61.210, createdTime=Tue Nov 08 17:19:00 CST 2011, time=2011-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605622, encodeId=4d6616056220e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Nov 07 15:51:00 CST 2011, time=2011-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3600, encodeId=395b3600f6, content=medsci评论真精彩,不愧是有水平的公司, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Nov 06 01:24:00 CST 2011, time=2011-11-06, status=1, ipAttribution=)]
    2011-11-06 lovetcm

    medsci评论真精彩,不愧是有水平的公司

    0

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