Baidu
map

JCEM:进食氨基酸同样能产生肠促胰素效应

2015-01-19 angletears 译 MedSci原创

肠促胰素效应,是指同等量的葡萄糖,口服比静脉注射更能促进移动啊素分泌,这与肠道分泌的两种肠促胰岛素,GIP和GLP-1有关。据研究,口服葡萄糖后,70%-80%的胰岛素分泌与肠促胰素效应有关。但是,这种肠促胰素效应不仅仅只存在于碳水化合物,很可能与其他宏观营养素有关。之前,来自瑞典的Ola Lindgren和他的团队,已经证明,这种肠促胰素效应,在进食脂质时同样存在。最近,他们的研究进一步证明,进

肠促胰素效应,是指同等量的葡萄糖,口服比静脉注射更能促进移动啊素分泌,这与肠道分泌的两种肠促胰岛素,GIP和GLP-1有关。据研究,口服葡萄糖后,70%-80%的胰岛素分泌与肠促胰素效应有关。但是,这种肠促胰素效应不仅仅只存在于碳水化合物,很可能与其他宏观营养素有关。之前,来自瑞典的Ola Lindgren和他的团队,已经证明,这种肠促胰素效应,在进食脂质时同样存在。最近,他们的研究进一步证明,进食氨基酸同样产生肠促胰素效应。


研究者选取12位男性非糖尿病志愿者,平均年龄在22.5±1.4岁,平均BMI22.4±1.4 kg/m2,,分别给予相同浓度的氨基酸口服或静脉注射。

试验中,测量餐后120min的胰岛素、C肽、胰高血糖素、GLP-1、GIP的曲线下面积(AUC),及胰岛素分泌率和胰岛素清除率



结果,胰岛素、C肽、胰高血糖素水平在口服和静脉注射氨基酸时,均升高了。但是,口服氨基酸时,胰岛素的分泌率比静脉注射的高25%。然而,胰高血糖素的反应在口服和静脉注射两种情况下,并无差别。

他们得出结论,给予同等水平的氨基酸,口服比静脉注射,可促进更多的胰岛素分泌,这与餐后GIP的水平迅速升高有关,这提示,口服氨基酸后引发的肠促胰岛素效应,很可能是由GIP介导的。

原始出处:

Lindgren O1, Pacini G, Tura A, Holst JJ, Deacon CF, Ahrén B.Incretin Effect after Oral Amino Acid Ingestion in Humans.J Clin Endocrinol Metab. 2014 Dec 9:jc20143865. [Epub ahead of print]


本文是MedSci原创编译整理,欢迎转载!转载请注明来源并附原文链接。谢谢!


您还可以这样阅读,更多资讯,请关注MedSci微信
  

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2062887, encodeId=004a206288ecf, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Sep 12 15:41:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944906, encodeId=d1e01944906e4, content=<a href='/topic/show?id=88678152506' target=_blank style='color:#2F92EE;'>#肠促胰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81525, encryptionId=88678152506, topicName=肠促胰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bcd409, createdName=xfpan12, createdTime=Sun Mar 29 20:41:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860820, encodeId=52db18608205d, content=<a href='/topic/show?id=5e746403ed5' target=_blank style='color:#2F92EE;'>#氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64037, encryptionId=5e746403ed5, topicName=氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Aug 06 10:41:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777505, encodeId=6a721e77505fc, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Sep 15 14:41:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585106, encodeId=c1db158510622, content=<a href='/topic/show?id=625c9440e39' target=_blank style='color:#2F92EE;'>#进食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94407, encryptionId=625c9440e39, topicName=进食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94cc17130334, createdName=gj0737, createdTime=Wed Jan 21 02:41:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-09-12 achengzhao
  2. [GetPortalCommentsPageByObjectIdResponse(id=2062887, encodeId=004a206288ecf, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Sep 12 15:41:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944906, encodeId=d1e01944906e4, content=<a href='/topic/show?id=88678152506' target=_blank style='color:#2F92EE;'>#肠促胰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81525, encryptionId=88678152506, topicName=肠促胰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bcd409, createdName=xfpan12, createdTime=Sun Mar 29 20:41:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860820, encodeId=52db18608205d, content=<a href='/topic/show?id=5e746403ed5' target=_blank style='color:#2F92EE;'>#氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64037, encryptionId=5e746403ed5, topicName=氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Aug 06 10:41:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777505, encodeId=6a721e77505fc, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Sep 15 14:41:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585106, encodeId=c1db158510622, content=<a href='/topic/show?id=625c9440e39' target=_blank style='color:#2F92EE;'>#进食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94407, encryptionId=625c9440e39, topicName=进食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94cc17130334, createdName=gj0737, createdTime=Wed Jan 21 02:41:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2062887, encodeId=004a206288ecf, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Sep 12 15:41:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944906, encodeId=d1e01944906e4, content=<a href='/topic/show?id=88678152506' target=_blank style='color:#2F92EE;'>#肠促胰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81525, encryptionId=88678152506, topicName=肠促胰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bcd409, createdName=xfpan12, createdTime=Sun Mar 29 20:41:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860820, encodeId=52db18608205d, content=<a href='/topic/show?id=5e746403ed5' target=_blank style='color:#2F92EE;'>#氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64037, encryptionId=5e746403ed5, topicName=氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Aug 06 10:41:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777505, encodeId=6a721e77505fc, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Sep 15 14:41:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585106, encodeId=c1db158510622, content=<a href='/topic/show?id=625c9440e39' target=_blank style='color:#2F92EE;'>#进食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94407, encryptionId=625c9440e39, topicName=进食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94cc17130334, createdName=gj0737, createdTime=Wed Jan 21 02:41:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2062887, encodeId=004a206288ecf, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Sep 12 15:41:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944906, encodeId=d1e01944906e4, content=<a href='/topic/show?id=88678152506' target=_blank style='color:#2F92EE;'>#肠促胰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81525, encryptionId=88678152506, topicName=肠促胰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bcd409, createdName=xfpan12, createdTime=Sun Mar 29 20:41:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860820, encodeId=52db18608205d, content=<a href='/topic/show?id=5e746403ed5' target=_blank style='color:#2F92EE;'>#氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64037, encryptionId=5e746403ed5, topicName=氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Aug 06 10:41:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777505, encodeId=6a721e77505fc, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Sep 15 14:41:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585106, encodeId=c1db158510622, content=<a href='/topic/show?id=625c9440e39' target=_blank style='color:#2F92EE;'>#进食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94407, encryptionId=625c9440e39, topicName=进食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94cc17130334, createdName=gj0737, createdTime=Wed Jan 21 02:41:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-09-15 smallant2015
  5. [GetPortalCommentsPageByObjectIdResponse(id=2062887, encodeId=004a206288ecf, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Sep 12 15:41:00 CST 2015, time=2015-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944906, encodeId=d1e01944906e4, content=<a href='/topic/show?id=88678152506' target=_blank style='color:#2F92EE;'>#肠促胰素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81525, encryptionId=88678152506, topicName=肠促胰素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6bcd409, createdName=xfpan12, createdTime=Sun Mar 29 20:41:00 CST 2015, time=2015-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1860820, encodeId=52db18608205d, content=<a href='/topic/show?id=5e746403ed5' target=_blank style='color:#2F92EE;'>#氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64037, encryptionId=5e746403ed5, topicName=氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Aug 06 10:41:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777505, encodeId=6a721e77505fc, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Tue Sep 15 14:41:00 CST 2015, time=2015-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585106, encodeId=c1db158510622, content=<a href='/topic/show?id=625c9440e39' target=_blank style='color:#2F92EE;'>#进食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94407, encryptionId=625c9440e39, topicName=进食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=94cc17130334, createdName=gj0737, createdTime=Wed Jan 21 02:41:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-01-21 gj0737

相关资讯

JCI:增加肠促胰素分泌细胞数目,促进胰岛素的分泌

肠促胰岛素GLP-1有很强的促进胰岛素分泌的作用,以GLP-1为基础的药物已经广泛用于2型糖尿病的治疗。这些药物包括,GLP-1受体激动剂和DPPVI抑制剂。临床中,以GLP-1为基础的治疗可以改善T2DM的血糖情况,以广泛被认可。但是,这些药物并不是通过模拟生理性的与饮食相关的GLP-1浓度的升降情况,来增加胰岛素分泌的。文献报道,肠道中的GLP-1分泌细胞L细胞起源于早期的分泌腺祖细胞。这些祖

胰岛素注射规范方法

胰岛素注射规范方法

JAMA Intern Med:治疗老年糖尿病患者不能一刀切

近日,来自耶鲁大学的研究人员通过研究表示,尽管糖尿病疗法可以挽救很多人的生命,但是在那些患多种疾病的老年患者中,利用胰岛素和磺脲类药物过度控制血糖或许会引发患者治疗过度及低血糖症,相关研究刊登于国际著名杂志JAMA Internal Medicine上。 文章中,研究者发现,许多老年的糖尿病患者不管其机体的健康状况和血糖水平如何,往往会接受过度的疗法来治疗疾病;在65岁及以上的老年糖尿病患者中,

J Alzheimers Dis:鼻腔喷雾式胰岛素有效治疗痴呆症

近日,发表在国际杂志J Alzheimers Dis上的一篇研究报告中,来自美国威克森林浸信医学中心(Wake Forest Baptist Medical Center)的研究人员通过研究表示,一种人造胰岛素鼻腔喷雾运输装置或可有效改善成年痴呆症及轻度认知损伤个体的工作记忆以及其它的精神能力。 文章中,研究者对60名诊断为遗忘型轻度认知损害(MCI)或轻度至中度阿尔兹海默氏症痴呆(AD)患者进

鼻腔喷雾式胰岛素有效治疗痴呆症

近日,发表在国际杂志J Alzheimers Dis上的一篇研究报告中,来自美国威克森林浸信医学中心(Wake Forest Baptist Medical Center)的研究人员通过研究表示,一种人造胰岛素鼻腔喷雾运输装置或可有效改善成年痴呆症及轻度认知损伤个体的工作记忆以及其它的精神能力。 文章中,研究者对60名诊断为遗忘型轻度认知损害(MCI)或轻度至中度阿尔兹海

JLB:某些T细胞可能在胰岛素抵抗中发挥作用

一项利用小鼠开展的新研究表明,一类不寻常型的免疫细胞即所谓的“γδT细胞”可能是一种新药物靶标,可用于治疗或预防肥胖引起的2型糖尿病。 该研究报告发表在Journal of Leukocyte Biology杂志上,研究表明γδT细胞对于肥胖诱导的巨噬细胞聚集(巨噬细胞聚集与脂肪组织中炎症相关)是必需的。 这种炎症是肥胖引起的,被认为是胰岛素抵抗和2型糖尿病的危险因素,但其根本原因尚未明确

Baidu
map
Baidu
map
Baidu
map