Baidu
map

Am J Sports Med:自体脂肪干细胞治疗膝关节炎安全、有效

2018-01-06 佚名 “Cell”微信号

近期,韩国首尔大学几位学者的一篇文章填补了自体脂肪组织来源的间充质干细胞通过关节腔注射治疗膝关节炎安全有效性评估在中期研究上的空白。

近期,韩国首尔大学几位学者的一篇文章填补了自体脂肪组织来源的间充质干细胞通过关节腔注射治疗膝关节炎安全有效性评估在中期研究上的空白。

骨关节炎是老年人致残的首要原因。

在55 - 60岁阶段,骨关节炎的发病率急剧上升。60岁以上达60%,75岁以上超过80%。

更残酷的是,骨关节炎是一种退行性疾病,目前没有根治的可能。

近几年,细胞治疗成为骨关节炎研究的热点。针对骨关节炎及类似疾病,国外已经上市了两款细胞药物。

一款是比利时2009年批准上市的ChondroCelect,来源于自体软骨的细胞治疗制品。

而2012年韩国批准的退行性关节炎干细胞制剂Cartistem的主要成分是脐带血间充质干细胞。

与此同时,国内外也有了大量通过关节腔注射间充质干细胞来治疗骨关节炎的临床研究,但普遍研究周期较短,主要是3 - 6个月。

2017年10月,《美国运动医学杂志》刊发了Chris Hyunchul Jo 等韩国学者的一篇文章。

Chris Hyunchul Jo 等人对他们此前一项临床试验的受试者进行了为期2年的随访调查。

结果表明,在2年时间内,关节腔注射自体脂肪组织来源的间充质干细胞治疗膝关节炎安全、有效。

这项研究是一项 I/II期临床试验(NCT01300598)的随访研究。临床试验开始于2009年3月,结束于2011年9月。

18位受试者(年龄跨度52 - 72岁,平均年龄61.8岁)被平均分配到 I期和 II期临床试验。按注射的细胞量又可分为低剂量组、中剂量组、高剂量组(1.0 x 10^7, 5.0 x 10^7, 1.0 x 10^8)。

主要结果

关节腔注射自体脂肪组织来源的间充质干细胞治疗膝关节炎,未见严重不良反应(包括但不限于肿瘤、异常软骨及骨组织生长)。

无论是低剂量组、中剂量组或高剂量组,间充质干细胞注射都能在2年内改善膝关节功能,减轻膝关节疼痛。

中低剂量组的临床改善在1年后趋于退化,只有高剂量组在2年内的临床改善有统计学意义。高剂量组的WOMAC评分显着降低。相比初始值,6个月下降39.4%,1年时下降70%,2年时仍降低64.9%。而中低剂量组的改善没有统计学意义。

受试者的MRI评估结果也表现出与临床症状同样的趋势。

以上研究结果表明,临床结果与注射的脂肪间充质干细胞数量密切相关。尽管机制尚不清楚,研究者认为这些细胞对关节软骨的直接再生作用可能大于其旁分泌效应。

这项研究的另一个重要发现是关节腔注射脂肪间充质干细胞后,关节软骨持续再生的临床及结构证据。而此前缺乏反应相关治疗效果持续性的研究结果。

为了更稳定的评估,避免错误,随访研究使用了与初始研究一致的评估工具。

当然,现在作者也认为初始试验设计存在一些不足:

样本量小;未设计对照组;未探讨治疗机制;中剂量组在1年时未随访;缺失1年时MRI数据;还可以增加更多的评估手段;未考虑关节镜探查清理术的积极影响;未研究

注射治疗后的最佳非承重期

脂肪间充质干细胞治疗膝关节炎的安全性和有效性已有大量的文献支持。这篇文献的意义则在于提供了更长观察周期的安全有效性证据。

同时,我们也期待有更多、设计更完善、更长观察期的临床研究来进一步论证关节腔注射脂肪间充质干细胞治疗膝关节炎的安全性和有效性。

原始出处:

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=276932, encodeId=ec5c2e6932b7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c21615377, createdName=xiongjie743, createdTime=Tue Jan 09 18:27:29 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265623, encodeId=a75112656234c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438995, encodeId=76fc143899525, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521531, encodeId=45441521531b7, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544061, encodeId=e449154406117, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608423, encodeId=8692160842332, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276045, encodeId=e7ba2e6045ba, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jan 06 16:40:18 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
    2018-01-09 xiongjie743

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=276932, encodeId=ec5c2e6932b7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c21615377, createdName=xiongjie743, createdTime=Tue Jan 09 18:27:29 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265623, encodeId=a75112656234c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438995, encodeId=76fc143899525, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521531, encodeId=45441521531b7, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544061, encodeId=e449154406117, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608423, encodeId=8692160842332, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276045, encodeId=e7ba2e6045ba, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jan 06 16:40:18 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
    2018-01-08 lmm397
  3. [GetPortalCommentsPageByObjectIdResponse(id=276932, encodeId=ec5c2e6932b7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c21615377, createdName=xiongjie743, createdTime=Tue Jan 09 18:27:29 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265623, encodeId=a75112656234c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438995, encodeId=76fc143899525, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521531, encodeId=45441521531b7, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544061, encodeId=e449154406117, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608423, encodeId=8692160842332, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276045, encodeId=e7ba2e6045ba, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jan 06 16:40:18 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=276932, encodeId=ec5c2e6932b7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c21615377, createdName=xiongjie743, createdTime=Tue Jan 09 18:27:29 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265623, encodeId=a75112656234c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438995, encodeId=76fc143899525, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521531, encodeId=45441521531b7, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544061, encodeId=e449154406117, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608423, encodeId=8692160842332, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276045, encodeId=e7ba2e6045ba, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jan 06 16:40:18 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=276932, encodeId=ec5c2e6932b7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c21615377, createdName=xiongjie743, createdTime=Tue Jan 09 18:27:29 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265623, encodeId=a75112656234c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438995, encodeId=76fc143899525, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521531, encodeId=45441521531b7, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544061, encodeId=e449154406117, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608423, encodeId=8692160842332, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276045, encodeId=e7ba2e6045ba, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jan 06 16:40:18 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=276932, encodeId=ec5c2e6932b7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c21615377, createdName=xiongjie743, createdTime=Tue Jan 09 18:27:29 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265623, encodeId=a75112656234c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438995, encodeId=76fc143899525, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521531, encodeId=45441521531b7, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544061, encodeId=e449154406117, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608423, encodeId=8692160842332, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276045, encodeId=e7ba2e6045ba, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jan 06 16:40:18 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=276932, encodeId=ec5c2e6932b7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c21615377, createdName=xiongjie743, createdTime=Tue Jan 09 18:27:29 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265623, encodeId=a75112656234c, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1438995, encodeId=76fc143899525, content=<a href='/topic/show?id=dd2884346fe' target=_blank style='color:#2F92EE;'>#脂肪干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84346, encryptionId=dd2884346fe, topicName=脂肪干细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521531, encodeId=45441521531b7, content=<a href='/topic/show?id=17a38586839' target=_blank style='color:#2F92EE;'>#膝关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85868, encryptionId=17a38586839, topicName=膝关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e3311361699, createdName=jiafufeng@yaho, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544061, encodeId=e449154406117, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e74a13632472, createdName=ms4964546379600229, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608423, encodeId=8692160842332, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jan 08 05:15:00 CST 2018, time=2018-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276045, encodeId=e7ba2e6045ba, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jan 06 16:40:18 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
    2018-01-06 虈亣靌

    学习了谢谢作者分享!

    0

相关资讯

J Rheumatol:手部骨关节炎的运动:Cochrane系统评价

低质量的证据表明运动对手部疼痛,功能和手指关节僵硬有小到中等的益处。

我国骨关节炎患者超1亿 人工智能或将实现骨科诊疗全流程覆盖

在今天(12月19日)举行的云栖大会·北京峰会上,唯医网与阿里云签署合作协议,共同探索人工智能在骨科领域的应用。

Sci Rep:MSCs来源的外泌体或囊泡可保护骨关节炎患者的软骨

间充质干细胞或基质细胞(MSCs)可在骨关节炎(OA)患者中发挥软骨保护作用。其作用发挥主要是通过可溶性介质介导的,这些介质可以在细胞外囊泡(EVs)内传递。本研究旨在比较外泌体(Exos)或微泡/微粒(MP)在OA中的作用。通过差速离心从小鼠骨髓BM-MSC中分离MPs和Exos。评估MPs或Exos对OA样小鼠软骨细胞的作用,并通过RT-qPCR定量软骨保护素。结果显示,在OA样软骨细胞中,B

Arthritis Rheumatol:骨关节炎和类风湿性关节炎患者中非甾体类抗炎药安全性的差异

在骨关节炎和类风湿性关节炎中,与布洛芬和萘普生相比,批准剂量的塞来昔布心血管、胃肠道和肾脏不良事件的风险相似或更低。

PLos One:体质指数对吸烟与原发性骨关节炎髋膝关节置换间关系的介导效应

吸烟对关节置换风险的影响大部分仍未被BMI解释。

J Rheumatol:滑膜细胞来源的白细胞介素35增强骨关节炎和类风湿性关节炎的B细胞反应

这是首次证实滑膜/外周B细胞表达IL-35R并对IL-35刺激有反应。

Baidu
map
Baidu
map
Baidu
map