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PloS Med:维生素D能缓解哮喘和特应性皮炎吗?

2017-05-10 枫丹白露 来宝网

根据加拿大麦吉尔大学布伦特理查兹的PLOS医学发表的一项新研究,维生素D补充剂不可能降低儿童或成人哮喘、特应性皮炎或过敏症的风险。

根据加拿大麦吉尔大学布伦特理查兹的PLOS医学发表的一项新研究,维生素D补充剂不可能降低儿童或成人哮喘、特应性皮炎或过敏症的风险。

一些以前的流行病学研究表明,低维生素D水平与哮喘,特应性皮炎(皮肤发痒的炎症)和IgE水平(与特应性疾病(过敏)相关的免疫分子)水平升高有关。在新的工作中,研究人员从以前的大型研究中,对超过10万人的遗传和健康数据进行了研究,以确定与维生素D水平相关的遗传改变是否会使人们患哮喘,皮炎或升高IgE水平。

研究人员发现在有或没有与25-羟基维生素D的较低水平相关的四种遗传变化中的任何一种患者中,哮喘(包括儿童期发作性哮喘),特应性皮炎或IgE水平之间没有统计学上的显着性差异。然而,结果不排除1,25-二羟维生素D(维生素的活性形式)的结果和水平之间的关联,并且需要更多的工作来确定非欧洲人群和维生素D缺乏症的结果是否正确。

Davis研究所的首席作者和Despoina Manousaki博士说:“我们的研究结果表明,以前的维生素D和特应性疾病之间的关联可能是由于与其他因素的虚假联系。 ”增加维生素D水平的努力可能不会导致成人和儿科哮喘,特应性皮炎或IgE水平升高的风险降低。

这些发现与同一组的最近的一项研究相反,该研究使用类似的方法提供支持维生素D在多发性硬化症(一种常见神经障碍)风险中的因果作用的证据。 Richards博士说:“我们以前的研究结果表明,低维生素D水平会增加一些炎症性疾病如多发性硬化症的风险,但这些影响并不会转化为其他炎性疾病,如哮喘和特应性皮炎。多发性硬化症的风险在一些人群中升高,包括欧洲血统和妇女的白人,这些发现表明,患有多发性硬化症风险的人应确保其具有足够的维生素D水平,但是增加维生素D的努力不会防止哮喘。

原始出处:

Despoina Manousaki,et al. Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study. PLOS MEDPublished: May 9, 2017https://doi.org/10.1371/journal.pmed.1002294

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    2017-06-26 1e1263e3m20(暂无匿称)

    学习了,多谢分享

    0

  2. 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    2017-05-30 laoli

    学习了,谢谢分享!

    0

  3. 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  4. 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    2017-05-11 cqykthl

    试验结果为阴性,没能获益

    0

  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 11 01:01:07 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 绛珠草小姐

    学习了,谢谢

    0

  6. 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    2017-05-11 大爰

    学习并分享!!!

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 11 01:01:07 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 1ddf0692m34(暂无匿称)

    学习了,涨知识

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 11 01:01:07 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 刘煜

    学习了谢谢分享。

    0

  9. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 11 01:01:07 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 飛歌

    学习了很有用

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 11 01:01:07 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 半夏微凉

    学习了谢谢分享

    0

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日前,发表于《美国骨科协会》的文章中指出,全球近10亿人口正在面临缺乏维生素D引起的慢性疾病,而这一切可能是由于防晒霜等带来的日照不足。 研究人员发现,95%的非籍美国人都存在维生素D不足的情况。“人们外出时间变少,即使出门,也会做好防晒,可是这一步骤却抵消了身体产生维生素D的能力。虽然我们希望人们做好防晒工作,以确保免受皮肤癌的困扰,然而适当的日照有助于提高身体的维生素D水平。”&nb

Pediatr Allergy Immunol:花粉季节中,患有季节过敏性鼻炎儿童维生素D水平的评估

血清维生素D在季节过敏性鼻炎(SAR)儿童中的水平并未被研究。最近,研究人员评估了在花粉季节中,患有SAR儿童维生素D的水平并与健康儿童的维生素D水平进行了比较。研究群体包括了100名SAR儿童和100名健康的对照。在4月到7月间,研究人员对所有的参与则进行了临床和实验室评估以及维生素D水平分析,并利用皮肤点刺试验在病人组中对花粉的敏感性进行检测。另外,研究人员比较了病人和对照组的25(OH)D3

Lancet Diabetes Endo:补充维生素D不会降低健康中老年人骨折风险

每月100000 IU VD高剂量补充不会降低健康中老年人群发生跌倒和骨折的风险

J Am Osteopath Assoc:防晒霜是导致维生素D不足的罪魁祸首

日前,发表于《美国骨科协会》的文章中指出,全球近10亿人口正在面临缺乏维生素D引起的慢性疾病,而这一切可能是由于防晒霜等带来的日照不足。

Diabetes Care:维生素D补充对2型糖尿病伴维生素D缺乏患者胰岛素敏感性和胰岛素分泌的影响!

由此可见,T2D伴有低维生素D的患者补充大剂量的维生素D3没有改变胰岛素敏感性和胰岛素分泌。这些研究结果并不支持采用维生素D3的补充治疗来改善T2D患者的血糖稳态。

J Am Osteopath Assoc:如何有效补充维生素D

夏季来临,防晒霜被认为是保护皮肤防止晒伤的关键。然而,一项最新研究表明,使用防晒霜可能存在一个显着缺点:即它可能会导致维生素D缺乏。

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