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IJC:血清sRANKL/OPG可预测孤立性房颤经导管射频消融术后复发

2013-12-25 佚名 丁香园

Kaplan–Meier生存曲线显示了LAF患者导管消融术后AF复发的减少 包括:AF持续时间(A)、左房直径(B)、血清sRANKL水平(C)和sRANKL/OPG比例(D) 研究要点: 1.RFCA是一种广泛接受的局灶性AF的治疗策略。OPG/RANK/RANKL轴可能通过调节心房结构重构从而促进AF发生和进展。 2.本研究旨在确定血清可

研究要点

1.RFCA是一种广泛接受的局灶性AF的治疗策略。OPG/RANK/RANKL轴可能通过调节心房结构重构从而促进AF发生和进展。

2.本研究旨在确定血清可溶性RANKL (sRANKL)/OPG水平与孤立性AF消融术后再发心律失常风险之间的关系。

3.该研究发现,血清高sRANKL水平与sRANKL/OPG比例基线与孤立性房颤首次消融术后AF复发有关,并可能被用于预测这些患者的AF复发。

经导管射频消融术(RFCA)是一种广泛接受的局灶性心房颤动(AF)的治疗策略,术后较高的复发率一定程度上是由心房重构引起。骨保护素(OPG)/κB因子的核受体激动剂(RANK)/RANK配体(RANKL)轴可能通过调节心房结构重构从而促进AF发生和进展。针对这种情况,为确定血清可溶性RANKL (sRANKL)/OPG水平与孤立性AF消融术后再发心律失常风险之间的关系,来自南京医科大学无锡人民医院心血管中心和南京鼓楼医院心胸外科的曹海龙博士等人进行了一项研究,研究结果发表于2013年8月International journal of cardiology杂志上。作者发现血清sRANKL/OPG可预测孤立性房颤经导管射频消融术后复发。

该研究共纳入了527名首次接受RFCA的孤立性AF患者,并登记了完整的随访资料。同时收集了消融术前静脉血样,用于血清sRANKL和OPG水平的检测。

在15(3–64)个月的随访期间,AF在187名患者中复发(35.5%)。复发与血清sRANKL水平及sRANKL/OPG比例的升高有关。在多元回归分析中,永久性AF、AF持续时间、左房直径、消融术后胺碘酮,尤其是血清sRANKL水平和sRANKL/OPG比例可独立的预测AF复发。根据ROC曲线分析,最具有预测复发价值的血清sRANKL水平和sRANKL/OPG比例分别为4.89 pmol/l和0.76.该研究发现,血清高sRANKL水平与sRANKL/OPG比例基线与孤立性房颤首次消融术后AF复发有关,并可能被用于预测这些患者的AF复发。

研究背景:

心房颤动(AF)是临床实践中最常见的心律失常,引起显著的发病率、致残率并常导致生活质量的下降。经导管射频消融术(RFCA)被认为是一种对有症状患者的合理有效的治疗选择,但复发率较高。复发的机制并不完全清楚,然而,心房重构和特殊心房结构的重构(ASR)可以反应一系列的病理生理变化,这些变化在AF复发中担任重要角色。这对于独立性AF(LAF)尤其适用,LAF被定义为无基础心脏病或心律失常伴随疾病的AF.

对临床危险因素和ASR程度的生化标志物的辨认,以及对RFCA术后AF复发的预测具有很高的临床重要性,并且正在被仔细研究。据显示,骨保护素(OPG)的组织表达增加、κB因子核受体激动剂配体(RANKL)和RANKL/OPG比例,可以可靠地反应OPG/RANK/RANKL轴的活性,并且在动物模型和心衰患者中均证明与基质降解和炎症细胞浸润有关。一项社区性的流行病学研究显示,循环OPG水平与AF发生率相关。

近期,我们和其他人已经证明,RANKL、诱骗受体和OPG间的相互作用在AF的发病机制和复发中扮演重要角色,这一作用可能是通过 预防基质降解和/或减轻局部炎症与细胞凋亡而实现的。

此研究旨在检测血清可溶性RANKL (sRANKL)/OPG水平作为生化标志物对于LAF患者RFCA术后AF复发风险的预测。

原文出处:

Hailong Cao, Ying Wu, Qingguo Li, Yanhu Wu, Qing Zhou, Oluf Dimitri Røe, Yijiang Chen, Ruxing Wange, Dongjin Wang.Serum sRANKL/OPG predict recurrence after radiofrequency catheter ablation of lone atrial fibrillation☆.International Journal of Cardiology 1 January 2014, accepted 28 August 2013. 

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  4. 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  5. 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  6. 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encodeId=8c7d152561487, content=<a href='/topic/show?id=2ef14545092' target=_blank style='color:#2F92EE;'>#孤立性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45450, encryptionId=2ef14545092, topicName=孤立性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb511649913, createdName=jxrzshh, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560229, encodeId=eb401560229c8, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566238, encodeId=0bcc156623878, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=)]
    2013-12-27 fzwish20002
  7. 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createdAvatar=null, createdBy=febc29728754, createdName=zhmscau, createdTime=Mon Jul 28 01:27:00 CST 2014, time=2014-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991800, encodeId=e7ce19918004f, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Fri Apr 18 07:27:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279901, encodeId=156b12e990192, content=<a href='/topic/show?id=0b0546822fd' target=_blank style='color:#2F92EE;'>#射频消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15115, encryptionId=1a2b151156f, topicName=RANKL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1966767752, createdName=fzwish20002, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510021, encodeId=f8a215100211c, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525614, encodeId=8c7d152561487, content=<a href='/topic/show?id=2ef14545092' target=_blank style='color:#2F92EE;'>#孤立性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45450, encryptionId=2ef14545092, topicName=孤立性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb511649913, createdName=jxrzshh, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560229, encodeId=eb401560229c8, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566238, encodeId=0bcc156623878, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=)]
    2013-12-27 lsj631
  8. [GetPortalCommentsPageByObjectIdResponse(id=1793038, encodeId=24a21e9303837, content=<a href='/topic/show?id=d228151167f' target=_blank style='color:#2F92EE;'>#RANKL/OPG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15116, encryptionId=d228151167f, topicName=RANKL/OPG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Mon Mar 03 02:27:00 CST 2014, time=2014-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694704, encodeId=215a1694e0427, content=<a href='/topic/show?id=471d4682409' target=_blank style='color:#2F92EE;'>#射频消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46824, encryptionId=471d4682409, topicName=射频消融术)], attachment=null, authenticateStatus=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15115, encryptionId=1a2b151156f, topicName=RANKL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1966767752, createdName=fzwish20002, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510021, encodeId=f8a215100211c, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525614, encodeId=8c7d152561487, content=<a href='/topic/show?id=2ef14545092' target=_blank style='color:#2F92EE;'>#孤立性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45450, encryptionId=2ef14545092, topicName=孤立性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb511649913, createdName=jxrzshh, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560229, encodeId=eb401560229c8, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566238, encodeId=0bcc156623878, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=)]
    2013-12-27 jxrzshh
  9. [GetPortalCommentsPageByObjectIdResponse(id=1793038, encodeId=24a21e9303837, content=<a href='/topic/show?id=d228151167f' target=_blank style='color:#2F92EE;'>#RANKL/OPG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15116, encryptionId=d228151167f, topicName=RANKL/OPG)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Mon Mar 03 02:27:00 CST 2014, time=2014-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694704, encodeId=215a1694e0427, content=<a href='/topic/show?id=471d4682409' target=_blank style='color:#2F92EE;'>#射频消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46824, encryptionId=471d4682409, topicName=射频消融术)], attachment=null, authenticateStatus=null, 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27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566238, encodeId=0bcc156623878, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=)]
  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15115, encryptionId=1a2b151156f, topicName=RANKL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1966767752, createdName=fzwish20002, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510021, encodeId=f8a215100211c, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e010191378, createdName=lsj631, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525614, encodeId=8c7d152561487, content=<a href='/topic/show?id=2ef14545092' target=_blank style='color:#2F92EE;'>#孤立性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45450, encryptionId=2ef14545092, topicName=孤立性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdb511649913, createdName=jxrzshh, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560229, encodeId=eb401560229c8, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566238, encodeId=0bcc156623878, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Fri Dec 27 01:27:00 CST 2013, time=2013-12-27, status=1, ipAttribution=)]
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