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Neurology：I型强直性肌营养不良脑影像学研究

2017-08-07 zhangfan MedSci原创

I型强直性肌营养不良MRICT
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对于I型强直性肌营养不良患者，脑影像学显示广泛的白质和灰质病变

近日研究人员对I型强直性肌营养不良(DM1)的脑成像研究进行了综述。研究对1946-2016年间的I型强直性肌营养不良的磁共振成像(MRI)、磁共振波谱学(MRS)、功能MRI、CT、超声、PET以及SPECT研究进行统计分析。从81个相关研究中提取临床特征、主要终点、临床遗传相关性和对潜在风险的信息偏差。对患者的结果和影像学异常进行汇总。对于DM1患者，其脑部影像学变化广泛，解剖特异性小。研究发现患者一般特征为脑萎缩和广泛的皮质叶、基底神经节和小脑灰质体积减少。研究发现，患者白质高信号比例较大（70% vs 6%)。DT1患者脑叶平均扩散率增加但白质连接各向异性分数降低。功能性研究表明患者额叶、顶叶和颞叶的葡萄糖摄取和脑灌注减少。研究表明，对于I型强直性肌营养不良患者，脑影像学显示广泛的白质和灰质病变。原始出处：Kees Okkersen et al. Brain imaging in myotonic dystrophy type 1 A systematic review. Neurology. August 2 2017.本文系梅斯医学（MedSci）原创编译整理，转载需授权！

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    2018-06-29 yinhl1978

    #Neurol#

    0

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    2017-09-25 zywlvao

    #强直性#

    0

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    2017-08-25 751943081_32627960

    #肌营养不良#

    0

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