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Nutr Metab Cardiovasc Dis:STEMI患者直接PCI后体内维生素D与胆固醇水平的关系

2022-02-07 “ 心关注 ”公众号 “ 心关注 ”公众号

在接受直接血运重建的急性ST段抬高型心肌梗死(STEMI)患者中,较低的维生素D水平与易致动脉粥样硬化的脂质谱独立相关;在接受他汀类药物治疗或未接受过他汀类药物治疗的患者中也观察到了类似的结果。

近日,发表在Nutr Metab Cardiovasc Dis杂志上的一项研究表明,在接受直接血运重建的急性ST段抬高型心肌梗死(STEMI)患者中,较低的维生素D水平与易致动脉粥样硬化的脂质谱独立相关;在接受他汀类药物治疗或未接受过他汀类药物治疗的患者中也观察到了类似的结果。

鉴于维生素D水平对脂质代谢的影响,以及可能对降脂治疗产生的干扰,研究者对450例接受PCI治疗的STEMI患者进行了回顾性分析。通过化学发光免疫分析测定血清25-(OH)D水平。

结果显示,较低的维生素D水平与较高的利尿剂使用率(P=0.03)、较低的分叉病变发生率(P=0.001)、较小的靶冠状动脉血管直径(P=0.03)和较高的冠状动脉钙化水平(P=0.007)相关维生素D水平较低的患者其总胆固醇和低密度脂蛋白胆固醇水平显着升高(P=0.05和P=0.005);与总胆固醇水平(r=-0.09,P=0.06)和LDL-C(r=-013,P=0.007)成反比,并与HDL-C水平(r=0.16,P=0.001)直接相关。

该结果不受他汀类药物治疗的影响,在他汀类药物治疗的患者中也证实了维生素D水平与致动脉粥样硬化的脂质谱存在显着关系,但与HDL-C水平无关。在多变量分析中,较低的维生素D水平是LDL-C升高或高于目标值的独立预测因子(OR 2.6,95%CI 1.51-4.44;P=0.001)。

 

原始出处:

M Verdoia et al. Relationship between vitamin D and cholesterol levels in STEMI patients undergoing primary percutaneous coronary intervention. Nutr Metab Cardiovasc Dis (2021).

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    2022-04-08 quxin068
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    2022-11-22 xuyu
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    2022-05-23 guojianrong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1939312, encodeId=698e1939312e4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 08 12:50:53 CST 2022, time=2022-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749122, encodeId=02611e491221a, content=<a href='/topic/show?id=843ee2425a1' target=_blank style='color:#2F92EE;'>#直接PCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72425, encryptionId=843ee2425a1, topicName=直接PCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cef136235391, createdName=xuyu, createdTime=Tue Nov 22 09:50:53 CST 2022, time=2022-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013805, encodeId=689d20138057a, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Feb 14 06:50:53 CST 2022, time=2022-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888405, encodeId=a84118884058c, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon May 23 05:50:53 CST 2022, time=2022-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896974, encodeId=b51818969e492, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Mar 04 09:50:53 CST 2022, time=2022-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936745, encodeId=dcae1936e45fa, content=<a href='/topic/show?id=74bd16e850c' target=_blank style='color:#2F92EE;'>#STEMI患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16785, encryptionId=74bd16e850c, topicName=STEMI患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Wed May 04 01:50:53 CST 2022, time=2022-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191223, encodeId=a01c1191223ca, content=新发现,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 21:06:50 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1482339, encodeId=a057148233992, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Tue Feb 08 05:50:53 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
    2022-03-04 一闲
  6. [GetPortalCommentsPageByObjectIdResponse(id=1939312, encodeId=698e1939312e4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 08 12:50:53 CST 2022, time=2022-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749122, encodeId=02611e491221a, content=<a href='/topic/show?id=843ee2425a1' target=_blank style='color:#2F92EE;'>#直接PCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72425, encryptionId=843ee2425a1, topicName=直接PCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cef136235391, createdName=xuyu, createdTime=Tue Nov 22 09:50:53 CST 2022, time=2022-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013805, encodeId=689d20138057a, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Feb 14 06:50:53 CST 2022, time=2022-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888405, encodeId=a84118884058c, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon May 23 05:50:53 CST 2022, time=2022-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896974, encodeId=b51818969e492, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Mar 04 09:50:53 CST 2022, time=2022-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936745, encodeId=dcae1936e45fa, content=<a href='/topic/show?id=74bd16e850c' target=_blank style='color:#2F92EE;'>#STEMI患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16785, encryptionId=74bd16e850c, topicName=STEMI患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Wed May 04 01:50:53 CST 2022, time=2022-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191223, encodeId=a01c1191223ca, content=新发现,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 21:06:50 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1482339, encodeId=a057148233992, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Tue Feb 08 05:50:53 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1939312, encodeId=698e1939312e4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Apr 08 12:50:53 CST 2022, time=2022-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749122, encodeId=02611e491221a, content=<a href='/topic/show?id=843ee2425a1' target=_blank style='color:#2F92EE;'>#直接PCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72425, encryptionId=843ee2425a1, topicName=直接PCI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cef136235391, createdName=xuyu, createdTime=Tue Nov 22 09:50:53 CST 2022, time=2022-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013805, encodeId=689d20138057a, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Mon Feb 14 06:50:53 CST 2022, time=2022-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888405, encodeId=a84118884058c, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Mon May 23 05:50:53 CST 2022, time=2022-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896974, encodeId=b51818969e492, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Mar 04 09:50:53 CST 2022, time=2022-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936745, encodeId=dcae1936e45fa, content=<a href='/topic/show?id=74bd16e850c' target=_blank style='color:#2F92EE;'>#STEMI患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16785, encryptionId=74bd16e850c, topicName=STEMI患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Wed May 04 01:50:53 CST 2022, time=2022-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1191223, encodeId=a01c1191223ca, content=新发现,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=89ae6481716, createdName=ms3000000637975859, createdTime=Tue Feb 08 21:06:50 CST 2022, time=2022-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1482339, encodeId=a057148233992, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Tue Feb 08 05:50:53 CST 2022, time=2022-02-08, status=1, ipAttribution=)]
    2022-02-08 ms3000000637975859

    新发现,值得学习

    0

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JAMA子刊:人口老龄化已经来临,如何更好的预防老年人跌倒发生?

随着全球人口的老龄化,跌倒和与跌倒相关的伤害无处不在

Clin Trans Gastroenterology:炎症性肠病患者铁缺乏与维生素D水平较低有关

炎性肠病又称炎症性肠病(IBD),为累及回肠、直肠、结肠的一种特发性肠道炎症性疾病。临床表现腹泻、腹痛,甚至可有血便。本病包括溃疡性结肠炎(UC)和克罗恩病(CD)。

BMJ:你可以永远相信维生素D和omega3——不论单独还是合并补充,两者均可以降低自身免疫性疾病发生!

补充维生素D五年,无论是否补充omega3脂肪酸,都能减少22%的自身免疫性疾病,而补充omega3脂肪酸,无论是否补充维生素D,都能减少15%的自身免疫性疾病率。

Lancet子刊:意外——“万金油”维生素D并不能降低死亡率!

综上,每月给未经筛查的老年人服用维生素D3并不能降低全因死亡率。

JCEM:维生素D在COVID-19预后和治疗中的作用

涉及近200万成年人的多项观察性研究表明,维生素D缺乏/不足会增加对COVID-19和严重COVID-19的易感性,尽管存在较高的偏倚和异质性风险。

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