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Cell:剑桥革命性新技术能更快筛选抗癌药物并公开数据

2016-09-26 佚名 生物探索

导语:根据9月22日发表在Cell上,英国癌症研究基金支持的一项研究文章报道:剑桥大学的科学家发现了一项新技术,可以很快地测试数百种抗癌药物,大大减少发现潜在的乳腺癌治疗方法的时间。他们向全球公开此项技术的数据。剑桥大学的科学家发现检测药物的新方法,可以加快乳腺癌治疗手段的发展。根据9月22日发表在Cell上,英国癌症研究基金支持的一项研究文章报道:这项新技术可以很快地测试数百种抗癌药物,大大减少

导语:根据9月22日发表在Cell上,英国癌症研究基金支持的一项研究文章报道:剑桥大学的科学家发现了一项新技术,可以很快地测试数百种抗癌药物,大大减少发现潜在的乳腺癌治疗方法的时间。他们向全球公开此项技术的数据。

剑桥大学的科学家发现检测药物的新方法,可以加快乳腺癌治疗手段的发展。根据9月22日发表在Cell上,英国癌症研究基金支持的一项研究文章报道:这项新技术可以很快地测试数百种抗癌药物,大大减少发现潜在的乳腺癌治疗方法的时间。

研究人员先在小鼠体内培养人乳腺癌细胞,再用实验药物进行进一步的测试。

以这种方式生长的细胞更能准确地模拟人身体中的癌细胞生长,并更接近地反映出在患者的癌细胞中发现的基因缺陷。这种方法意味着更多的药物可以在相同的时间以不同的组合进行测试,可能缩短为患者提供新的药物所需的时间。



该项目新的研究方法减少了试验中使用的小鼠数量,同时使药物测试更加准确。这种新技术意味着研究人员从小鼠体内将癌细胞再转移出来后,可以进行数百种药物的试验。此项技术将取代目前在塑料培养皿中培养癌细胞的然后再在小鼠身上测试的实践。目前的方法的局限性在于肿瘤细胞在塑料培养皿中的生长是异于在身体中的。

英国癌症研究中心剑桥研究所所长、剑桥乳腺癌研究的领导者,通讯作者Carlos Caldas教授说:“传统上我们都在培养基中培养细胞,但这是人工的,因为在体内细胞以更负责的方式生长。在将来,这种新技术,和他人一样,将取代实验室中今天使用的方法。”

Carlos Caldas教授介绍:“我们正在做的是将我们所有的数据公开,世界各地的其它研究人员可以使用和收益于我们的工作,我们会继续改进它。”

英国癌症研究中心的高级科学信息经理Nell Barrie说:“寻找更准确和有效的新方法来检测对抗癌症的潜在药物是非常重要的。这样的研究可以帮助我们更快地找到新的治疗方法,也有助于确定特定患者群体的药物的最佳组合,以确保更多的人能从疾病中生存下来。”

原始出处:

Bruna A1, Rueda OM1, Greenwood W1, Batra AS1, Callari M1, Batra RN1, Pogrebniak K1, Sandoval J1, Cassidy JW1, Tufegdzic-Vidakovic A1, Sammut SJ1, Jones L2, Provenzano E3, Baird R2, Eirew P4, Hadfield J1, Eldridge M1, McLaren-Douglas A5, Barthorpe A5, Lightfoot H5, O'Connor MJ6, Gray J7, Cortes J8, Baselga J9, Marangoni E10, Welm AL11, Aparicio S4, Serra V8, Garnett MJ5, Caldas C12.A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.Cell. 2016 Sep 22

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    2017-02-22 维他命
  4. [GetPortalCommentsPageByObjectIdResponse(id=1869563, encodeId=f75a18695630a, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Nov 29 02:04:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903726, encodeId=9b591903e26ec, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Thu Jun 08 19:04:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959822, encodeId=8b50195982276, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 22 04:04:00 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138846, encodeId=fc5813884651, content=很好,很有帮助,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 10:32:49 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308224, encodeId=c4e0130822486, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Sep 28 00:04:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314678, encodeId=9d9713146e8d9, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Sep 28 00:04:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584358, encodeId=d3c7158435893, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Wed Sep 28 00:04:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135858, encodeId=d88f13585837, content=以后多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160927/IMG57EA05AC632186996.jpg, createdBy=cb591958173, createdName=医者自医, createdTime=Tue Sep 27 13:05:08 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-10-02 右脚梅西

    很好,很有帮助,谢谢

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1869563, encodeId=f75a18695630a, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Nov 29 02:04:00 CST 2016, time=2016-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903726, encodeId=9b591903e26ec, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Thu Jun 08 19:04:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959822, encodeId=8b50195982276, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed Feb 22 04:04:00 CST 2017, time=2017-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138846, encodeId=fc5813884651, content=很好,很有帮助,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160930/IMG57EDFF4739EBF3035.jpg, createdBy=0da11618734, createdName=右脚梅西, createdTime=Sun Oct 02 10:32:49 CST 2016, time=2016-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308224, encodeId=c4e0130822486, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Sep 28 00:04:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314678, encodeId=9d9713146e8d9, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Sep 28 00:04:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584358, encodeId=d3c7158435893, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Wed Sep 28 00:04:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135858, encodeId=d88f13585837, content=以后多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160927/IMG57EA05AC632186996.jpg, createdBy=cb591958173, createdName=医者自医, createdTime=Tue Sep 27 13:05:08 CST 2016, time=2016-09-27, status=1, ipAttribution=)]
    2016-09-28 sunylz
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    2016-09-27 医者自医

    以后多学习

    0

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