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中华糖尿病杂志:从大型心血管结局研究分析糖尿病患者早期强化降糖策略

2017-07-31 佚名 中华医学信息导报

中国糖尿病患病率已高达9.7%,患病人数居世界首位。糖尿病及其相关并发症给社会带来了巨大的负担。2型糖尿病患者(T2DM)的心血管疾病风险是非糖尿病患者的2~4倍。尽管高血糖已被证实是心血管疾病的独立危险因素,但强化降糖治疗是否能够减少心血管并发症尚无定论。由于患者基线的差异、降糖目标及随访时间的不同,强化降糖治疗对心血管结局的影响不尽相同。本文从大型心血管结局研究入手,分析糖尿病患者早期强化降糖

中国糖尿病患病率已高达9.7%,患病人数居世界首位。糖尿病及其相关并发症给社会带来了巨大的负担。2型糖尿病患者(T2DM)的心血管疾病风险是非糖尿病患者的2~4倍。尽管高血糖已被证实是心血管疾病的独立危险因素,但强化降糖治疗是否能够减少心血管并发症尚无定论。由于患者基线的差异、降糖目标及随访时间的不同,强化降糖治疗对心血管结局的影响不尽相同。本文从大型心血管结局研究入手,分析糖尿病患者早期强化降糖策略的有效性,对临床医师有一定的启发意义。

陆菊明(解放军总医院内分泌科)指出,高血糖尤其是餐后血糖升高会诱导氧化应激、引起系统性炎症反应和内皮损伤等,进而促进动脉粥样硬化和心血管事件的发生。另一方面,低血糖造成的低能量供给使心肌收缩加强、心输出量增多、心肌自主神经病变和功能障碍,进而可能增加心肌梗死的风险。此外,低血糖还会增加死亡风险。

T2DM患者选择合适的早期强化降糖策略可带来远期的心血管获益,早诊断、早治疗,早期消除高血糖的“代谢记忆”效应,是糖尿病管理的重要策略。大型心血管结局研究在一定程度上提供了早期强化降糖策略的临床实践参考,即进行早期干预、选择合适的人群、坚持长期随访等。随着循证医学证据的积累和临床实践的深入,心血管疾病风险与高血糖及其他影响因素的关系会更加清晰,以进一步指导和完善糖尿病的早期管理策略。

原始出处:
陆菊明. 从大型心血管结局研究分析糖尿病患者早期强化降糖策略 [J]. 中华糖尿病杂志,2017,9( 6 ): 406-408. DOI: 10.3760/cma.j.issn.1674-5809.2017.06.016

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    2017-08-01 thlabcde

    好东西学习了!

    0

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    2017-08-01 changjiu

    学习了,谢谢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2003847, encodeId=b303200384e35, content=<a href='/topic/show?id=4d8650150ce' target=_blank style='color:#2F92EE;'>#强化降糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50150, encryptionId=4d8650150ce, topicName=强化降糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3547346, createdName=dongjia2010, createdTime=Tue Jun 19 19:21:00 CST 2018, time=2018-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818712, encodeId=64471818e12d9, content=<a href='/topic/show?id=f5a8981e84d' target=_blank style='color:#2F92EE;'>#降糖策略#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98178, encryptionId=f5a8981e84d, topicName=降糖策略)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Sep 17 16:21:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269312, encodeId=e7ee1269312c3, content=<a href='/topic/show?id=49d1518915a' target=_blank style='color:#2F92EE;'>#心血管结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51891, encryptionId=49d1518915a, topicName=心血管结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Wed Aug 02 08:21:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474273, encodeId=e7b714e4273c6, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Aug 02 08:21:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228927, encodeId=255c22892e46, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Aug 01 21:47:21 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228617, encodeId=275f22861e65, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue Aug 01 02:07:09 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228533, encodeId=6b7a22853378, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jul 31 18:56:33 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228516, encodeId=c019228516bc, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Jul 31 17:35:59 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 惠映实验室

    学习了,谢谢。

    0

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    2017-07-31 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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