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西安杨森欧洲申请将依他胺鼻腔喷雾剂用于治疗抑郁症

2018-10-11 MedSci MedSci原创

西安杨森Janssen公司向欧洲药品管理局(EMA)提交了一份销售申请,要求批准其研究的依他胺鼻腔喷雾剂用于治疗重度抑郁症。

西安杨森Janssen公司向欧洲药品管理局(EMA)提交了一份销售申请,要求批准其研究的依他胺鼻腔喷雾剂用于治疗重度抑郁症。

依他胺(Esketamine)是一种谷氨酸受体调节剂,被认为有助于恢复抵抗性抑郁症(TRD)患者脑细胞的突触连接,这是30年以来该类疾病第一个新药。该药物在此之前已批准用于治疗对两种不同的抗抑郁药治疗无应答的TRD成年患者。

该公司今年早些时候提供的数据显示,持续使用依他胺鼻腔喷雾剂联用口服抗抑郁药治疗超过16周,与安慰剂鼻腔喷雾剂联用口服抗抑郁药相比,患者的复发风险降低了51%。

Janssen Research&Development神经科学治疗领域全球负责人Husseini K. Manji说:"我们的III期研究结果强化了esketamine鼻喷剂作为一种新型治疗方法的潜力,该药物将可以帮助那些对现有疗法没有应答的患者。"

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2023894, encodeId=ef9d2023894c5, content=<a href='/topic/show?id=99ff64628fb' target=_blank style='color:#2F92EE;'>#治疗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64628, encryptionId=99ff64628fb, topicName=治疗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Sat Aug 10 13:17:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994953, encodeId=5c53199495350, content=<a href='/topic/show?id=eb8f10351e38' target=_blank style='color:#2F92EE;'>#鼻腔喷雾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103517, encryptionId=eb8f10351e38, topicName=鼻腔喷雾)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Fri Oct 12 03:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339127, encodeId=c6be133912e01, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424970, encodeId=87a614249e03d, content=<a href='/topic/show?id=d42b90494af' target=_blank style='color:#2F92EE;'>#西安杨森#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90494, encryptionId=d42b90494af, topicName=西安杨森)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a73942387, createdName=qindq, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465842, encodeId=dd1e14658424c, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543215, encodeId=d2f01543215bf, content=<a href='/topic/show?id=f2be61592eb' target=_blank style='color:#2F92EE;'>#杨森#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61592, encryptionId=f2be61592eb, topicName=杨森)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=421413558235, createdName=陆成振, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348947, encodeId=cbd734894e75, content=不错的文章值得拥有,, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Oct 11 22:52:10 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2018-10-13 mnda
  6. [GetPortalCommentsPageByObjectIdResponse(id=2023894, encodeId=ef9d2023894c5, content=<a href='/topic/show?id=99ff64628fb' target=_blank style='color:#2F92EE;'>#治疗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64628, encryptionId=99ff64628fb, topicName=治疗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Sat Aug 10 13:17:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994953, encodeId=5c53199495350, content=<a href='/topic/show?id=eb8f10351e38' target=_blank style='color:#2F92EE;'>#鼻腔喷雾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103517, encryptionId=eb8f10351e38, topicName=鼻腔喷雾)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Fri Oct 12 03:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339127, encodeId=c6be133912e01, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424970, encodeId=87a614249e03d, content=<a href='/topic/show?id=d42b90494af' target=_blank style='color:#2F92EE;'>#西安杨森#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90494, encryptionId=d42b90494af, topicName=西安杨森)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a73942387, createdName=qindq, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465842, encodeId=dd1e14658424c, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543215, encodeId=d2f01543215bf, content=<a href='/topic/show?id=f2be61592eb' target=_blank style='color:#2F92EE;'>#杨森#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61592, encryptionId=f2be61592eb, topicName=杨森)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=421413558235, createdName=陆成振, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348947, encodeId=cbd734894e75, content=不错的文章值得拥有,, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Oct 11 22:52:10 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2018-10-13 陆成振
  7. [GetPortalCommentsPageByObjectIdResponse(id=2023894, encodeId=ef9d2023894c5, content=<a href='/topic/show?id=99ff64628fb' target=_blank style='color:#2F92EE;'>#治疗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64628, encryptionId=99ff64628fb, topicName=治疗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Sat Aug 10 13:17:00 CST 2019, time=2019-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994953, encodeId=5c53199495350, content=<a href='/topic/show?id=eb8f10351e38' target=_blank style='color:#2F92EE;'>#鼻腔喷雾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103517, encryptionId=eb8f10351e38, topicName=鼻腔喷雾)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Fri Oct 12 03:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339127, encodeId=c6be133912e01, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424970, encodeId=87a614249e03d, content=<a href='/topic/show?id=d42b90494af' target=_blank style='color:#2F92EE;'>#西安杨森#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90494, encryptionId=d42b90494af, topicName=西安杨森)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7a73942387, createdName=qindq, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465842, encodeId=dd1e14658424c, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543215, encodeId=d2f01543215bf, content=<a href='/topic/show?id=f2be61592eb' target=_blank style='color:#2F92EE;'>#杨森#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61592, encryptionId=f2be61592eb, topicName=杨森)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=421413558235, createdName=陆成振, createdTime=Sat Oct 13 10:17:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348947, encodeId=cbd734894e75, content=不错的文章值得拥有,, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Thu Oct 11 22:52:10 CST 2018, time=2018-10-11, status=1, ipAttribution=)]
    2018-10-11 1e1b8538m79(暂无匿称)

    不错的文章值得拥有,

    0

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