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JAMA Pediatr:先天性Zika病毒感染的眼科筛查标准

2017-07-23 Yara MedSci原创

眼睛异常可能是目前先天性Zika病毒感染的唯一初步发现。在怀孕期间任何时候,所有在母体中暴露于Zika病毒的婴儿无论是否存在中枢神经系统异常,均应接受眼睛检查。

目前,已经有推荐的方法用于鉴定患有小脑或者Zika感染婴儿的眼部检查,但是还缺乏相应的方法对在子宫内暴露于Zika感染的婴儿进行检查。该研究的目的是在孕妇怀孕期间,通过PCR反应来评估Zika病毒感染的婴儿队列中的眼部检查结果。

从2016年1月2日到10月30日,在婴儿从出生到一岁期间,一个多学科的组成的医疗团队对他们进行了检查,该团队包括:儿科眼科医生,Fernandes Figueira研究所人员,巴西里约热内卢儿童高危妊娠和传染病中心。研究人员通过实时PCR测试了Zika病毒感染的母婴的血清,尿液,羊水或胎盘样品。

通过来源于母亲的标本,研究人员发现PCR确认的Zika病毒感染的112例中,24例婴儿(21.4%)被检查出有眼睛异常。眼睛异常的婴儿中有10名(41.7%)没有小头症,8名(33.3%)没有发现任何中枢神经系统异常。4例有眼部畸形的婴儿(58.3%)出生于妊娠早期感染Zika的妇女,8例(33.3%)为妊娠中期,2例(8.3%)为妊娠晚期。视神经和视网膜异常是最常见的畸形。眼睛异常与小头症,其他中枢神经系统异常,关节病和妊娠母亲感染时期具有数据上的相关性。

最后,研究人员得出结论:眼睛异常可能是目前先天性Zika病毒感染的唯一初步发现。在怀孕期间任何时候,所有在母体中暴露于Zika病毒的婴儿无论是否存在中枢神经系统异常,均应接受眼睛检查。

原文出处


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    2017-09-19 feather89
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    2017-07-25 huirong
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