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Lancet Oncol:多囊肾,警惕这些癌症

2016-09-08 Mechront 译 MedSci原创

本研究的目的旨在分析多囊肾患者固体固体癌症的风险。研究纳入了台湾1998年1月至2010年12月的≥20岁多囊肾患者,排除多囊肾患者、慢性肾脏病或终末期肾脏疾病患者。随访14年,主要终点为癌症诊断。研究纳入了4346例多囊肾患者和4346例非多囊肾对照组。多囊肾组和对照组中位随访时间分别为3·72年(IQR 1·25–7·31)和4·96年(2·29–8·38)。总癌症发病率在多囊肾病组更高(相比

本研究的目的旨在分析多囊肾患者固体固体癌症的风险。

研究纳入了台湾1998年1月至2010年12月的≥20岁多囊肾患者,排除多囊肾患者、慢性肾脏病或终末期肾脏疾病患者。随访14年,主要终点为癌症诊断。

研究纳入了4346例多囊肾患者和4346例非多囊肾对照组。多囊肾组和对照组中位随访时间分别为3·72年(IQR 1·25–7·31)和4·96年(2·29–8·38)。

总癌症发病率在多囊肾病组更高(相比对照组;20·1 [95% CI 18·3–21·9]/1000人年 vs 10·9 [10·1–11·8]/1000人年; cHR 1·77 [95% CI 1·52–2·07];aHR 1·83 [1·57–2·15](校正年龄、性别、就诊次数、合并症)。

对囊肾组的以下癌症风险显著高于对照组:肝癌(1·49 [95% CI 1·04–2·13]; p=0·030)、 结肠癌(1·63 [1·15–2·30]; p=0·006)、肾癌(2·45 [1·29–4·65]; p=0·006)。

这是首次调查非终末期肾脏疾病的多囊肾患者其癌症风险;这类患者的肝癌、结肠癌和肾癌显著更高,临床医务人员应清楚的认识到这一点,在诊疗过程中,意识到相应风险。

原始出处:

Tung-Min Yu.et al.Risk of cancer in patients with polycystic kidney disease: a propensity-score matched analysis of a nationwide, population-based cohort study.Lancet Oncol.Published Online: 19 August 2016

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    2017-04-20 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1828607, encodeId=d099182860e53, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 20 16:39:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864797, encodeId=26cc1864e97d6, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 31 21:39:00 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131126, encodeId=e4b11311260a, content=谢谢分享,很有用的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76f6105517, createdName=Jiangyh0406, createdTime=Tue Sep 20 00:10:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392866, encodeId=76d5139286615, content=<a href='/topic/show?id=4d28431606e' target=_blank style='color:#2F92EE;'>#多囊肾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43160, encryptionId=4d28431606e, topicName=多囊肾)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Sat Sep 10 05:39:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=114280, encodeId=4a91114280f9, content=学习啦,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Sep 08 17:41:00 CST 2016, time=2016-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=114229, encodeId=41a91142297e, content=学习了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Sep 08 17:31:00 CST 2016, time=2016-09-08, status=1, ipAttribution=)]
    2017-05-31 minlingfeng
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    2016-09-20 Jiangyh0406

    谢谢分享,很有用的信息

    0

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    2016-09-08 医路开来

    学习啦,谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1828607, encodeId=d099182860e53, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Apr 20 16:39:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864797, encodeId=26cc1864e97d6, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 31 21:39:00 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131126, encodeId=e4b11311260a, content=谢谢分享,很有用的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76f6105517, createdName=Jiangyh0406, createdTime=Tue Sep 20 00:10:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392866, encodeId=76d5139286615, content=<a href='/topic/show?id=4d28431606e' target=_blank style='color:#2F92EE;'>#多囊肾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43160, encryptionId=4d28431606e, topicName=多囊肾)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Sat Sep 10 05:39:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=114280, encodeId=4a91114280f9, content=学习啦,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Sep 08 17:41:00 CST 2016, time=2016-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=114229, encodeId=41a91142297e, content=学习了谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Sep 08 17:31:00 CST 2016, time=2016-09-08, status=1, ipAttribution=)]
    2016-09-08 刘煜

    学习了谢谢。

    0

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