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门静脉化疗栓塞预防肝癌切除术后复发

2012-04-27 小哲 摘编 医学论坛网

  近日,温州医学院附属第五医院吕昕亮、张坤、朱锦德等人共同发表论文,旨在探讨原发性肝细胞癌切除术后,经皮经肝门静脉穿刺化疗栓塞(PVCE)预防肿瘤复发的效果。研究指出,肝癌切除术后经皮经肝门静脉穿刺化疗栓塞能有效预防肿瘤复发。该文发表在2012年第18卷第1期《中华肝胆外科杂志》上。   回顾性分析温州医学院附属第五医院2007年1月至2010年1月89例肝癌手术切除患者临床资料。其中术后进行

  近日,温州医学院附属第五医院吕昕亮、张坤、朱锦德等人共同发表论文,旨在探讨原发性肝细胞癌切除术后,经皮经肝门静脉穿刺化疗栓塞(PVCE)预防肿瘤复发的效果。研究指出,肝癌切除术后经皮经肝门静脉穿刺化疗栓塞能有效预防肿瘤复发。该文发表在2012年第18卷第1期《中华肝胆外科杂志》上。

  回顾性分析温州医学院附属第五医院2007年1月至2010年1月89例肝癌手术切除患者临床资料。其中术后进行预防性经皮经肝门静脉穿刺化疗栓塞(治疗组)41例,未行预防性门静脉化疗栓塞(对照组)48例。随访术后肿瘤复发情况,应用Kaplan-Meier方法分析两组累积无瘤生存率。

  结果术后随访6~42个月。治疗组患者术后1年及2年无瘤生存率分别为76.5%、48.0%,对照组分别为53.8%、25.8%,差异有统计学意义;平均无瘤生存期分别为19.91个月和13.80个月,治疗组累积无瘤生存率高于对照组。Cox模型多因素分析显示:预防性门静脉化疗栓塞、肿瘤大小、术前门静脉癌栓、术后经导管动脉化疗栓塞(TACE)是影响患者肝癌切除术后复发的独立因素。
    

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