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JCC: 水果摄入量与溃疡性结肠炎微生物组成的改变和储袋炎的发生率降低有关

2019-10-03 不详 MedSci原创

溃疡性结肠炎[UC]的患者在接受回肠直肠吻合术后,通常会发生储袋炎[pouchitis]。本项研究探讨了饮食和微生物群的改变是否导致了储袋炎的发生。

背景
溃疡性结肠炎[UC]的患者在接受回肠直肠吻合术后,通常会发生储袋炎[pouchitis]。本项研究探讨了饮食和微生物群的改变是否导致了储袋炎的发生。

方法
研究人员招募溃疡性结肠炎患者并进行前瞻性随访。所有患者完成了“食物频率问卷” [FFQs]的调查。最后研究人员分析了粪便样品中的微生物组成[16S rRNA测序]。

结果
研究人员对172例患者[59%的女性]进行了营养评估,其中75例患者进行了粪便微生物分析(微生物群:NP [ n = 22],储袋炎[ n = 53])。水果消耗最低三分位数[<1.45份/天]的患者与那些消费量较高的患者相比,储袋炎的发生率更高[30.8% VS 3.8%,p = 0.03]。水果的消耗与微生物多样性[ r = 0.35,p = 0.002]和几种微生物属的丰富度有关,其中包括Faecalibacterium [r = 0.29,p = 0.01],Lachnospira [ r = 0.38,p = 0.001],以及Ruminococcaceae[ r = 0.25,p = 0.05]。随着病程的延长,水果消耗量的减少与疾病的复发和微生物多样性的降低有关[Δ= –0.8±0.3,p = 0.008]。

结论
食用水果与微生物组成的改变有关,而食用水果的减少与储袋炎的发展有关。因此,食用水果可以通过改变微生物组成来预防肠道炎症。

原始出处:

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    2020-04-04 nymo
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    2020-08-24 lmm397
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