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JAHA:血钠对射血分数正常的心衰患者的预后意义!

2018-06-13 xing.T MedSci原创

血清钠升高和降低,包括目前认为的正常范围,与射血分数正常的心力衰竭患者的不良结局相关。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究是在一个大型射血分数正常的心力衰竭患者的全国性队列中完成旨在评估心衰诊断时血清钠水平与长期临床结局之间的相关性。

研究人员分析了美国退伍军人事务中心2002至2012年间治疗的25440例射血分数正常的心力衰竭患者。在心衰诊断时的血清钠水平被作为连续变量进行分析,其分类如下:低血钠(115-134.99mmol/L)、正常偏低(135-137.99mmol/L)、参考组(138-140.99mmol/L)、正常偏高(141-143.99mmol/L)和高血钠(144-160mmol/L)。多变量Cox回归和负二项回归用于估计血清钠与死亡率和住院(心力衰竭和所有原因)之间关联的风险比(95%可信区间[CI])和发病密度比(95%CI)。

患者平均年龄为70.8岁,男性占96.2%,黑人占14%。与参考组相比,低血钠、正常偏低和高血钠组全因死亡风险分别增加36%(95%CI为28%-44%)、6%(95%CI为1%-12%)和9%(95%CI为1%-17%)。低血钠和正常偏低血清钠水平与每年心衰住院天数的风险分别增加48%(95%CI为10%-100%)和38%(95%CI为8%-77%)相关,并与每年全因住院天数的风险增加44%(95%CI为32%-56%)和18%(95%CI为10%-27%)相关。

血清钠升高和降低,包括目前认为的正常范围,与射血分数正常的心力衰竭患者的不良结局相关。

原始出处:

Yash R. Patel.et al. Prognostic Significance of Baseline Serum Sodium in Heart Failure With Preserved Ejection Fraction.JAHA.2018. https://doi.org/10.1161/JAHA.117.007529

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    2019-05-07 hmwwww
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    2018-06-15 zhaohui6731
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    2018-06-13 phoebeyan520

    谢谢分享.学习了

    0

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