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JASN:C反应蛋白自身抗体对狼疮肾炎补体活化及病程的影响!

2017-06-01 xing.T MedSci原创

该研究结果为人类疾病中体内mCRP的产生提供了证据,并表明mCRP可以通过调节补体活化来主动控制狼疮性肾炎的发病机制。因此,氨基酸35-47构成的CRP功能性自身免疫表位,可以有针对性的用于疾病治疗和诊断。

在狼疮性肾炎患者中针对急性期反应物C-反应蛋白(CRP)的自身抗体十分常见。进一步确定CRP自身免疫表位不仅可以改善患者的分层,而且提示CRP在其发病机制中的作用。

近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,研究人员发现狼疮性肾炎患者中氨基酸35-47构成了可被抗CRP自身抗体识别的主要抗原表位。值得注意的是,针对氨基酸35-47抗原表位的自身抗体存在与更严重的肾脏损害相关,并且可以预测患者更坏的结局。

只有在发生不可逆转的结构变化后该CRP表位才能暴露出来,得到构象改变的CRP形式称为改变的或单体CRP(mCRP)。ELISA和表面等离子体共振实验表明氨基酸35-47介导了mCRP与补体因子H的相互作用,补体因子H是替代途径激活的抑制剂,这种相互作用大大增强了补体因子H体外辅助活性。相反,针对氨基酸35-47的自身抗体可以抑制mCRP的这些行为。

该研究结果为人类疾病中体内mCRP的产生提供了证据,并表明mCRP可以通过调节补体活化来主动控制狼疮性肾炎的发病机制。因此,氨基酸35-47构成的CRP功能性自身免疫表位,可以有针对性的用于疾病治疗和诊断

原始出处:

Qiu-yu Li,et al. Autoantibodies against C-Reactive Protein Influence Complement Activation and Clinical Course in Lupus Nephritis.JASN,2017, http://jasn.asnjournals.org/content/early/2017/05/31/ASN.2016070735.abstract

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    2017-11-04 chenhongpeng
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    2017-06-03 villahu
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    2017-06-01 1ddf0692m34(暂无匿称)

    涨知识,学习

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