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JACC:△CHA2DS2-VASc能更好地预测房颤患者卒中发生的风险

2018-01-12 MedSci MedSci原创

目前,评估房颤患者缺血性卒中发生风险主要是通过CHA2DS2-VASc评分系统,而结局预后则是在随访一定时间后进行评估。然而这种评分系统有一个弊端,即房颤患者发生卒中的风险并不是静止不变的,在随访期间可能会发生变化。本研究的目的旨在利用新型的△CHA2DS2-VASc评分系统来反映房颤患者随访期间卒中风险发生的变化。本研究纳入了31039名没有接受抗血小板治疗的房颤患者,并且除了年龄和性别外无CH

目前,评估房颤患者缺血性卒中发生风险主要是通过CHA2DS2-VASc评分系统,而结局预后则是在随访一定时间后进行评估。然而这种评分系统有一个弊端,即房颤患者发生卒中的风险并不是静止不变的,在随访期间可能会发生变化。

本研究的目的旨在利用新型的△CHA2DS2-VASc评分系统来反映房颤患者随访期间卒中风险发生的变化。

本研究纳入了31039名没有接受抗血小板治疗的房颤患者,并且除了年龄和性别外无CHA2DS2-VASc评分系统中的并发症。△CHA2DS2-VASc评分则是指患者基线和随访期间CHA2DS2-VASc评分的差值。经过171956人年后,有4103名患者发生了缺血性卒中事件,研究者将基线CHA2DS2-VASc评分、随访后CHA2DS2-VASc评分和△CHA2DS2-VASc评分分别与患者预后进行相关性分析,并进行相互间比较。结果发现,患者基线的平均CHA2DS2-VASc评分为1.29,随访期间增加至2.31,平均△CHA2DS2-VASc评分为1.02。CHA2DS2-VASc评分仅在40.8%的患者中保持不变。在4103名发生缺血性卒中患者中,有89.4%的患者△CHA2DS2-VASc评分≥1,而无卒中患者中仅有54.6%△CHA2DS2-VASc评分≥1。△CHA2DS2-VASc评分在预测房颤患者缺血性卒中发生风险方面要优于基线和随访期间CHA2DS2-VASc评分。

研究结果显示,房颤患者发生缺血性卒中的风险并不是一成不变的,患者基线和随访期间CHA2DS2-VASc评分的差值(△CHA2DS2-VASc)能更好的预测患者卒中的发生风险。

原始出处:

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1782917, encodeId=479d1e82917bc, content=<a href='/topic/show?id=c1fa456550' target=_blank style='color:#2F92EE;'>#CHA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4565, encryptionId=c1fa456550, topicName=CHA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 16 03:48:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938781, encodeId=ae011938e8153, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Apr 24 10:48:00 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853903, encodeId=f758185390302, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 18 18:48:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325667, encodeId=53f4132566ed1, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Jan 14 00:48:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573493, encodeId=6b8115e349397, content=<a href='/topic/show?id=79b34566e1' target=_blank style='color:#2F92EE;'>#CHA2DS2-VASc#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4566, encryptionId=79b34566e1, topicName=CHA2DS2-VASc)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f2615885776, createdName=canlab, createdTime=Sun Jan 14 00:48:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614429, encodeId=bf3416144292a, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Sun Jan 14 00:48:00 CST 2018, time=2018-01-14, status=1, ipAttribution=)]
    2018-09-16 huperzia
  2. [GetPortalCommentsPageByObjectIdResponse(id=1782917, encodeId=479d1e82917bc, content=<a href='/topic/show?id=c1fa456550' target=_blank style='color:#2F92EE;'>#CHA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4565, encryptionId=c1fa456550, topicName=CHA2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Sep 16 03:48:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938781, encodeId=ae011938e8153, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Apr 24 10:48:00 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1853903, encodeId=f758185390302, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sun Nov 18 18:48:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325667, encodeId=53f4132566ed1, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Sun Jan 14 00:48:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573493, encodeId=6b8115e349397, content=<a href='/topic/show?id=79b34566e1' target=_blank style='color:#2F92EE;'>#CHA2DS2-VASc#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4566, encryptionId=79b34566e1, topicName=CHA2DS2-VASc)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5f2615885776, createdName=canlab, createdTime=Sun Jan 14 00:48:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614429, encodeId=bf3416144292a, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Sun Jan 14 00:48:00 CST 2018, time=2018-01-14, status=1, ipAttribution=)]
    2018-04-24 仁者大医
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    2018-11-18 hbwxf
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