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科学家开发出治疗恶性脑瘤的新型疗法

2015-11-27 佚名 生物谷

治疗恶性脑瘤
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图片来源：medicalxpress.com 近日，一项刊登在国际杂志Scientific Reports上的研究报告中，来自国外的科学家开发了一种治疗多形性胶质母细胞瘤(GBM)的新型疗法，多形性胶质母细胞瘤是目前最常见且致死性最高的一种原发性脑部肿瘤。 胶质母细胞瘤患者的5年生存率一般抵御10%，研究者Verbridge指出，目前胶质母细胞瘤的治疗并没有明显被改善，而且并没有疗法可以优

图片来源：medicalxpress.com

近日，一项刊登在国际杂志Scientific Reports上的研究报告中，来自国外的科学家开发了一种治疗多形性胶质母细胞瘤(GBM)的新型疗法，多形性胶质母细胞瘤是目前最常见且致死性最高的一种原发性脑部肿瘤。

胶质母细胞瘤患者的5年生存率一般抵御10%，研究者Verbridge指出，目前胶质母细胞瘤的治疗并没有明显被改善，而且并没有疗法可以优先靶向杀灭神经胶质瘤干细胞或弥散的浸润细胞，从而经常导致患者在手术、化疗或放疗法疾病复发。本文研究就描述了一种涉及脉冲电场( Pulsed Electric Fields)的新型疗法，其可以更好地靶向作用并且杀灭恶性细胞，同时还对健康细胞无影响。

胶质母细胞瘤通常对常规及靶向性的癌症疗法极其耐受，部分是因为肿瘤是由多种不同的癌症细胞组成，患者首次治疗后复发非常常见。本文研究中，研究者Davalos等人依据此前的一项专利设计出了新型的技术，此前专利主要是直接向肿瘤中插入电极来诱导肿瘤细胞出现不可逆的电穿孔（IRE），这种疗法可以成功用于治疗和患者病情相似的犬类脑瘤。

如今研究者开发了高频率版本的疗法（HFIRE），其可以利用脉冲引发细胞快速破裂，IRE和HFIRE都可以杀死肿瘤细胞，但机制却不同，IRE疗法可以通过感染细胞外膜来促进细胞死亡，而HFIRE则可以促进细胞核崩塌，由于该疗法可以靶向作用细胞核，因此研究者假设，相比正常细胞而言具有较大核的恶性细胞或许存在较低的阈值。

后期研究中研究人员将通过进行体内实验确定选择性的HFIRE消融疗法发挥功能的机制，研究者认为，将这种疗法同其他疗法相结合或许可以更加有效地杀灭侵袭性的胶质母细胞瘤细胞，从而为患者带来较大的健康效益。

原文出处：

Jill W. Ivey, Eduardo L. Latouche,et al.Targeted cellular ablation based on the morphology of malignant cells.Scientific Reports.2015

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    2015-11-30 smartjoy

    #新型疗法#

    0

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    2016-09-07 陈吴1234

    #恶性脑瘤#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1924860, encodeId=87c7192486034, content=<a href='/topic/show?id=7d1558259f5' target=_blank style='color:#2F92EE;'>#新型疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58259, encryptionId=7d1558259f5, topicName=新型疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Mon Nov 30 13:16:00 CST 2015, time=2015-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055902, encodeId=190320559022d, content=<a href='/topic/show?id=a8e1529484f' target=_blank style='color:#2F92EE;'>#恶性脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52948, encryptionId=a8e1529484f, topicName=恶性脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbf451, createdName=陈吴1234, createdTime=Wed Sep 07 20:16:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66929, encodeId=900666929ae, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Wed Mar 02 23:51:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47410, encodeId=58d34e4103e, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:19:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47409, encodeId=ae024e4091b, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:18:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46944, encodeId=558a469448a, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Dec 21 10:52:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44752, encodeId=a67b44e52e8, content=想起冬天上自习，坐在门口，总是有些进出不关门的人带给我的感受。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Fri Dec 04 14:15:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44648, encodeId=446044648ad, content=读, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLBzoPY0a1ZQrECBF90v8AkFiaxRlNpGj1mLzD1B7ibnyBjmDEjiauBSDpOw6w4tI7YxmjdWaIW0SXL4/0, createdBy=35951605658, createdName=等你一年又一年, createdTime=Thu Dec 03 22:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275661, encodeId=612d12e56611e, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Nov 29 00:16:00 CST 2015, time=2015-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43969, encodeId=91ef4396947, content=行，很好，很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Nov 27 12:32:00 CST 2015, time=2015-11-27, status=1, ipAttribution=)]
    2016-03-02 勇敢的医生

    真的假的

    0

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    2015-12-24 nizongzan

    恩

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1924860, encodeId=87c7192486034, content=<a href='/topic/show?id=7d1558259f5' target=_blank style='color:#2F92EE;'>#新型疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58259, encryptionId=7d1558259f5, topicName=新型疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Mon Nov 30 13:16:00 CST 2015, time=2015-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055902, encodeId=190320559022d, content=<a href='/topic/show?id=a8e1529484f' target=_blank style='color:#2F92EE;'>#恶性脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52948, encryptionId=a8e1529484f, topicName=恶性脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbf451, createdName=陈吴1234, createdTime=Wed Sep 07 20:16:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66929, encodeId=900666929ae, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Wed Mar 02 23:51:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47410, encodeId=58d34e4103e, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:19:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47409, encodeId=ae024e4091b, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:18:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46944, encodeId=558a469448a, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Dec 21 10:52:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44752, encodeId=a67b44e52e8, content=想起冬天上自习，坐在门口，总是有些进出不关门的人带给我的感受。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Fri Dec 04 14:15:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44648, encodeId=446044648ad, content=读, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLBzoPY0a1ZQrECBF90v8AkFiaxRlNpGj1mLzD1B7ibnyBjmDEjiauBSDpOw6w4tI7YxmjdWaIW0SXL4/0, createdBy=35951605658, createdName=等你一年又一年, createdTime=Thu Dec 03 22:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275661, encodeId=612d12e56611e, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Nov 29 00:16:00 CST 2015, time=2015-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43969, encodeId=91ef4396947, content=行，很好，很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Nov 27 12:32:00 CST 2015, time=2015-11-27, status=1, ipAttribution=)]
    2015-12-24 nizongzan

    好的

    0

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    2015-12-21 milkshark

    好文章

    0

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    2015-12-04 pangshiwei

    想起冬天上自习，坐在门口，总是有些进出不关门的人带给我的感受。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1924860, encodeId=87c7192486034, content=<a href='/topic/show?id=7d1558259f5' target=_blank style='color:#2F92EE;'>#新型疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58259, encryptionId=7d1558259f5, topicName=新型疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Mon Nov 30 13:16:00 CST 2015, time=2015-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055902, encodeId=190320559022d, content=<a href='/topic/show?id=a8e1529484f' target=_blank style='color:#2F92EE;'>#恶性脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52948, encryptionId=a8e1529484f, topicName=恶性脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbf451, createdName=陈吴1234, createdTime=Wed Sep 07 20:16:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66929, encodeId=900666929ae, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Wed Mar 02 23:51:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47410, encodeId=58d34e4103e, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:19:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47409, encodeId=ae024e4091b, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:18:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46944, encodeId=558a469448a, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Dec 21 10:52:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44752, encodeId=a67b44e52e8, content=想起冬天上自习，坐在门口，总是有些进出不关门的人带给我的感受。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Fri Dec 04 14:15:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44648, encodeId=446044648ad, content=读, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLBzoPY0a1ZQrECBF90v8AkFiaxRlNpGj1mLzD1B7ibnyBjmDEjiauBSDpOw6w4tI7YxmjdWaIW0SXL4/0, createdBy=35951605658, createdName=等你一年又一年, createdTime=Thu Dec 03 22:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275661, encodeId=612d12e56611e, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Nov 29 00:16:00 CST 2015, time=2015-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43969, encodeId=91ef4396947, content=行，很好，很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Nov 27 12:32:00 CST 2015, time=2015-11-27, status=1, ipAttribution=)]
    2015-12-03 等你一年又一年

    读

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1924860, encodeId=87c7192486034, content=<a href='/topic/show?id=7d1558259f5' target=_blank style='color:#2F92EE;'>#新型疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58259, encryptionId=7d1558259f5, topicName=新型疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Mon Nov 30 13:16:00 CST 2015, time=2015-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055902, encodeId=190320559022d, content=<a href='/topic/show?id=a8e1529484f' target=_blank style='color:#2F92EE;'>#恶性脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52948, encryptionId=a8e1529484f, topicName=恶性脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbf451, createdName=陈吴1234, createdTime=Wed Sep 07 20:16:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66929, encodeId=900666929ae, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Wed Mar 02 23:51:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47410, encodeId=58d34e4103e, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:19:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47409, encodeId=ae024e4091b, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:18:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46944, encodeId=558a469448a, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Dec 21 10:52:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44752, encodeId=a67b44e52e8, content=想起冬天上自习，坐在门口，总是有些进出不关门的人带给我的感受。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Fri Dec 04 14:15:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44648, encodeId=446044648ad, content=读, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLBzoPY0a1ZQrECBF90v8AkFiaxRlNpGj1mLzD1B7ibnyBjmDEjiauBSDpOw6w4tI7YxmjdWaIW0SXL4/0, createdBy=35951605658, createdName=等你一年又一年, createdTime=Thu Dec 03 22:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275661, encodeId=612d12e56611e, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Nov 29 00:16:00 CST 2015, time=2015-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43969, encodeId=91ef4396947, content=行，很好，很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Nov 27 12:32:00 CST 2015, time=2015-11-27, status=1, ipAttribution=)]
    2015-11-29 jxrzshh

    #脑瘤#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1924860, encodeId=87c7192486034, content=<a href='/topic/show?id=7d1558259f5' target=_blank style='color:#2F92EE;'>#新型疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58259, encryptionId=7d1558259f5, topicName=新型疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Mon Nov 30 13:16:00 CST 2015, time=2015-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055902, encodeId=190320559022d, content=<a href='/topic/show?id=a8e1529484f' target=_blank style='color:#2F92EE;'>#恶性脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52948, encryptionId=a8e1529484f, topicName=恶性脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cbf451, createdName=陈吴1234, createdTime=Wed Sep 07 20:16:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66929, encodeId=900666929ae, content=真的假的, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Wed Mar 02 23:51:00 CST 2016, time=2016-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47410, encodeId=58d34e4103e, content=恩, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:19:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47409, encodeId=ae024e4091b, content=好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Dec 24 07:18:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46944, encodeId=558a469448a, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Dec 21 10:52:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44752, encodeId=a67b44e52e8, content=想起冬天上自习，坐在门口，总是有些进出不关门的人带给我的感受。, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=67ce42087, createdName=pangshiwei, createdTime=Fri Dec 04 14:15:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44648, encodeId=446044648ad, content=读, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLBzoPY0a1ZQrECBF90v8AkFiaxRlNpGj1mLzD1B7ibnyBjmDEjiauBSDpOw6w4tI7YxmjdWaIW0SXL4/0, createdBy=35951605658, createdName=等你一年又一年, createdTime=Thu Dec 03 22:49:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275661, encodeId=612d12e56611e, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sun Nov 29 00:16:00 CST 2015, time=2015-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=43969, encodeId=91ef4396947, content=行，很好，很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Fri Nov 27 12:32:00 CST 2015, time=2015-11-27, status=1, ipAttribution=)]
    2015-11-27 lixh1719

    行，很好，很好

    0

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