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Molecules:淫羊藿苷通过降低血糖和抑制骨转换来预防糖尿病引起的骨丧失

2019-06-29 不详 网络

糖尿病性骨质疏松症(DOP)是一种常见的代谢性骨病,其特征在于骨矿物质密度(BMD)降低和骨微结构破坏。据报道,淫羊藿苷有益于雌激素缺乏引起的骨质疏松症和酒精引起的骨质疏松症;淫羊藿苷是否对糖尿病引起的骨质疏松症有保护作用尚未见报道。在本研究中,通过链脲佐菌素注射建立糖尿病性骨质疏松症大鼠模型,观察了淫羊藿苷对糖尿病引起的骨丢失的骨保护作用和潜在机制。将30只8周龄雌性Sprague Dawley

糖尿病骨质疏松症(DOP)是一种常见的代谢性骨病,其特征在于骨矿物质密度(BMD)降低和骨微结构破坏。据报道,淫羊藿苷有益于雌激素缺乏引起的骨质疏松症和酒精引起的骨质疏松症;淫羊藿苷是否对糖尿病引起的骨质疏松症有保护作用尚未见报道。

在本研究中,通过链脲佐菌素注射建立糖尿病性骨质疏松症大鼠模型,观察了淫羊藿苷对糖尿病引起的骨丢失的骨保护作用和潜在机制。将30只8周龄雌性Sprague Dawley大鼠分为对照组(载体治疗组),T1DM(糖尿病)组和T1DM-淫羊藿苷组(ICA)组(用淫羊藿苷治疗的糖尿病大鼠),每组10只大鼠。在淫羊藿苷给药8周后,分析骨组织形态学参数,骨矿物质密度(BMD),血清骨转换标志物和骨髓脂肪生成。

结果显示,100mg/kg剂量的淫羊藿苷降低了血糖,并增加了糖尿病大鼠的BMD。淫羊藿苷有效降低血清骨转换标志物水平,包括CTX-1,ALP,TRACP 5b,骨钙蛋白和PINP。同时,骨组织形态学参数,每个骨周长的破骨细胞数量变为正常水平,淫羊藿苷治疗抑制骨髓脂肪形成。在糖尿病大鼠的淫羊藿苷治疗后,血清和骨组织中的runt相关转录因子2(RUNX 2)以及骨保护素(OPG)/核因子-κB配体受体激活剂(RANKL)比例显著增加。

综上所述,该研究结果表明口服淫羊藿苷可预防糖尿病性骨质疏松症;其作用主要与其降低血糖,抑制骨转换和骨髓脂肪形成,以及上调骨RUNX 2和OPG表达的能力有关。

原始出处:

Qi S, He J, et al., Icariin Prevents Diabetes-Induced Bone Loss in Rats by Reducing Blood Glucose and Suppressing Bone Turnover. Molecules. 2019 May 15;24(10). pii: E1871. doi: 10.3390/molecules24101871.

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    2020-03-24 mei543
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    2019-07-01 wenjie
  6. [GetPortalCommentsPageByObjectIdResponse(id=1743578, encodeId=0ea01e43578ca, content=<a href='/topic/show?id=c3df1015e54d' target=_blank style='color:#2F92EE;'>#骨丧失#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101575, encryptionId=c3df1015e54d, topicName=骨丧失)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a0f35143673, createdName=mei543, createdTime=Tue Mar 24 05:35:00 CST 2020, time=2020-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820217, encodeId=54c5182021e68, content=<a href='/topic/show?id=854a100358e6' target=_blank style='color:#2F92EE;'>#预防糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100358, encryptionId=854a100358e6, topicName=预防糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sun May 31 20:35:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818692, encodeId=361a1818692d6, content=<a href='/topic/show?id=4119981338a' target=_blank style='color:#2F92EE;'>#降低血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98133, encryptionId=4119981338a, topicName=降低血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Sat May 09 06:35:00 CST 2020, time=2020-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951717, encodeId=64541951e176c, content=<a href='/topic/show?id=2abb6606e9e' target=_blank style='color:#2F92EE;'>#淫羊藿苷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66067, encryptionId=2abb6606e9e, topicName=淫羊藿苷)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3e9205, createdName=tidiq, createdTime=Wed Dec 25 11:35:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510576, encodeId=542015105e626, content=<a href='/topic/show?id=7400660665b' target=_blank style='color:#2F92EE;'>#淫羊藿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66066, encryptionId=7400660665b, topicName=淫羊藿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e0810213212, createdName=wenjie, createdTime=Mon Jul 01 06:35:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042548, encodeId=008c104254850, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jun 29 18:35:00 CST 2019, time=2019-06-29, status=1, ipAttribution=)]
    2019-06-29 misszhang

    谢谢MedSci提供最新的资讯

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