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JCEM:1型糖尿病成年人心血管疾病(CVD)的危险因素

2020-01-19 xing.T MedSci原创

由此可见,HbA1c、高血压、血脂异常和糖尿病肾病是1型糖尿病成人CVD的重要危险因素。可能需要更长的随访时间来评估其他传统CVD危险因素对CVD事件的影响。

血管疾病(CVD)是1型糖尿病成年人死亡的主要原因。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员前瞻性地评估了居住在美国的大型当代1型糖尿病成年人的CVD危险因素。

该研究为针对CVD和CVD危险因素中位随访5.3年的观察性研究。受试者入组前或入组时患有1型糖尿病且未确诊CVD的成人(≥18岁)。该研究通过多变量logistic回归评估了CVD危险因素与CVD之间的关联。

该研究纳入了8727名参与者(53%女性,88%非西班牙裔白人,中位年龄33岁[IQR=21-48],1型糖尿病病程16年[IQR=9-26])。入组时,HbA1c中位数为7.6%(66 mmol/mol)[IQR=6.9(52)-8.6(70)],33%参与者使用他汀类药物和37%参与者使用降压药。在平均4.6年的随访中,有325名(3.7%)参与者发生了CVD。缺血性心脏病是最常见的CVD事件。年龄、BMI和HbA1c增加、高血压和血脂异常、糖尿病持续时间增加和糖尿病肾病与CVD风险增加相关。CVD风险没有明显的性别差异。

由此可见,HbA1c、高血压、血脂异常和糖尿病肾病是1型糖尿病成人CVD的重要危险因素。可能需要更长的随访时间来评估其他传统CVD危险因素对CVD事件的影响。

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    2020-04-11 smallant2015
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    2020-07-23 achengzhao
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    2020-01-20 misszhang

    谢谢MedSci提供最新的资讯

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