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J Clin Periodontol:全身炎症对牙周炎与血糖状况关系的分析

2018-03-08 MedSci MedSci原创

本次横断面研究调查了牙周炎、全身炎症和血糖状态之间的关联。参与者分为三组:正常血糖,空腹血糖受损(IFG)和糖尿病。多项Logistic回归用于检查牙周炎严重程度与血糖状况之间的关联,校正潜在的混杂因素。对四种全身炎症标志物,C-反应蛋白(CRP),白细胞计数(WBC),中性粒细胞-淋巴细胞比率(NLR)和血小板-淋巴细胞比率(PLR)进行调解分析。研究共纳入2036名参与者,年龄39-66岁。严

本次横断面研究调查了牙周炎、全身炎症和血糖状态之间的关联。

参与者分为三组:正常血糖,空腹血糖受损(IFG)和糖尿病。多项Logistic回归用于检查牙周炎严重程度与血糖状况之间的关联,校正潜在的混杂因素。对四种全身炎症标志物,C-反应蛋白(CRP),白细胞计数(WBC),中性粒细胞-淋巴细胞比率(NLR)和血小板-淋巴细胞比率(PLR)进行调解分析。

研究共纳入2036名参与者,年龄39-66岁。严重的牙周炎与IFG和糖尿病的相关性分别为1.6(95%置信区间[CI]:1.1-2.4,p = 0.023)和2.4(95%CI:1.3-4.5,p = 0.006)。 CRP、WBC和PLR均与牙周炎严重程度和血糖状态有关(p <0.05)。相反,NLR与牙周炎严重程度(p <0.05)相关,但与血糖状态无关(p> 0.05)。 CRP、WBC和PLR介导的严重牙周炎与糖尿病之间的关联分别为8%、13%和6%。对于牙周炎与IFG关联也观察到类似的比例。

综上所述,该研究结果发现支持全身性炎症作为牙周炎与IFG或糖尿病之间关联的介体的作用。

原始出处:

Torrungruang K, Ongphiphadhanakul B, et al., Mediation analysis of systemic inflammation on the association between periodontitis and glycemic status. J Clin Periodontol. 2018 Mar 3. doi: 10.1111/jcpe.12884. [Epub ahead of print]

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    2018-03-26 feather89
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    2018-03-08 qingfengqishi5

    学习了.学习了

    0

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    2018-03-08 神功盖世

    0

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