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Crit Care Med:ICU获得性衰弱早期全身炎症增加!

2017-03-30 xing.T MedSci原创

由此可见,ICU获得性衰弱患者相比于没有发生ICU获得性衰弱患者在入住ICU后头4天内全身性炎症水平增加。这一发现是一致的,即使调整了混杂因素,如疾病的严重程度。一个由IL-6、IL-8、IL-10和趋化因子组成的组合被确认为是最重要的。

近日,危重病医学领域权威杂志Critical Care Medicine上发表了一篇研究文章,研究人员旨在调查重症监护室(ICU)获得性衰弱患者与重症但没有发生ICU获得性衰弱患者相比是否有不同的全身性炎症标记物。

该研究为前瞻性观察性队列研究。以荷兰三级教学医院的混合医疗-外科ICU为基础,其新入院的危重患者,且机械通气大于或等于48小时的没有神经系统疾病诊断的ICU入住者被纳入研究。研究人员在参与者入住ICU后0天、2天和4天测量了血浆样本中一组全身炎症标志物和可溶性血管粘附分子。ICU获得性衰弱通过手动肌力测试来诊断,一旦病人清醒。

研究人员发现204例纳入的参与者中有99例患者发生ICU获得性衰弱。校正混杂因素后的主成分回归分析发现主成分1,主要包括IL-6、IL-8、IL-10和趋化因子,在ICU获得性衰弱患者中明显升高(比值比为1.35[95%可信区间为1.18-1.55])。偏最小二乘判别分析还表明这些标记是最重要的判别标记。这些标记物的混合效应模型表明ICU获得性衰弱与这些标志物独立增加1.5-2倍有关。

由此可见,ICU获得性衰弱患者相比于没有发生ICU获得性衰弱患者在入住ICU后头4天内全身性炎症水平增加。这一发现是一致的,即使调整了混杂因素,如疾病的严重程度。一个由IL-6、IL-8、IL-10和趋化因子组成的组合被确认为是最重要的。

原始出处:

Witteveen, Esther, et al. Increased Early Systemic Inflammation in ICU-Acquired Weakness; A Prospective Observational Cohort Study.Critical Care Medicine.2017. http://journals.lww.com/ccmjournal/Abstract/publishahead/Increased_Early_Systemic_Inflammation_in.96661.aspx

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    2017-04-04 虈亣靌

    学习了谢谢作者分享!

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2042584, encodeId=fd7b204258486, content=<a href='/topic/show?id=999c88014ea' target=_blank style='color:#2F92EE;'>#获得性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88014, encryptionId=999c88014ea, topicName=获得性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4b7363, createdName=pandamao2010, createdTime=Sat Sep 16 14:33:00 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185144, encodeId=d51218514423, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Apr 04 18:06:48 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516549, encodeId=33dc15165491c, content=<a href='/topic/show?id=3b0329699d3' target=_blank style='color:#2F92EE;'>#全身炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29699, encryptionId=3b0329699d3, topicName=全身炎症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f6210986148, createdName=12498dd9m14暂无昵称, createdTime=Sat Apr 01 11:33:00 CST 2017, time=2017-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607350, encodeId=296a160e350cf, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Apr 01 11:33:00 CST 2017, time=2017-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183853, encodeId=7b5518385390, content=头一次听说这病, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRr4hYQTDrdLbsTChMzLetAadHkYtbdKribQFsv5vWbnhUYuQoVfqwW32yaOIO1BmBiaBPcSibicwgSAc/0, createdBy=5b192044357, createdName=流浪野医, createdTime=Thu Mar 30 22:36:18 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183850, encodeId=99ad183850f0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5Rzbfz86jX5QcxJAPcvMicc5G3HfNvborfwKUB03K6hlZlLtbZa3oyMutiaSAia1g3HPRcCuZkhVLKp44/0, createdBy=a8a72041783, createdName=笑忘书, createdTime=Thu Mar 30 22:16:32 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=183849, encodeId=797c18384906, content=第一次听说这种病!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Thu Mar 30 21:59:26 CST 2017, time=2017-03-30, status=1, ipAttribution=)]
    2017-03-30 流浪野医

    头一次听说这病

    0

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    2017-03-30 笑忘书

    学习了

    0

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    2017-03-30 thlabcde

    第一次听说这种病!

    0

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