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Annal Surgery:食管癌切除术后使用辅助化疗与新辅助化疗后使用辅助化疗的疗效比较

2017-07-28 xuyihan MedSci原创

食管癌切除术后使用辅助化疗(AC)与新辅助化疗后使用辅助化疗在影响食管癌患者的总体生存率方面是否有差异呢?最近一项研究比较了二者的区别。

食管癌切除术后使用辅助化疗(AC)与新辅助化疗后使用辅助化疗在影响食管癌患者的总体生存率方面是否有差异呢?最近一项研究比较了二者的区别。

新辅助化放疗目前是局部食管癌的首选治疗方法。虽然目前对辅助化疗的使用比较热门,但在新辅助放化疗和食管切除术后全身治疗的益处尚不清楚。

本项研究回顾性分析了2006-2012年间行新辅助化疗与食管切除术患者的生存率情况。共纳入3592名食管癌患者(84.7%腺癌,鳞状细胞癌15.2%),335例(9.3%)用AC治疗。其中没有残留疾病(ypT0N0)或残留非淋巴结疾病(ypT + N0)患者在使用AC后死亡风险显着降低。残留淋巴结病(ypTanyN +)患者中在术后90天评估,结果相似。术后住院时间平均≤10天,无入院患者,AC患者残留淋巴结转移患者死亡风险降低约40%。

从中我们可以看出:新辅助化放疗和食管切除术后使用AC与改善残留淋巴结病患者生存率有关。我们的研究结果表明AC可能为食管癌患者提供额外的益处,值得进一步调查。

原始出处:
Burt, Bryan M.et al.Utility of Adjuvant Chemotherapy After Neoadjuvant.Annals Surgery.2017

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    2017-10-24 chg121
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    2017-10-11 执迷不悔

    学习咯

    0

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    2017-08-08 星海孤魂

    学习了,谢谢

    0

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    2017-07-30 zhouqu_8
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