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Circulation:伴有心室收缩功能障碍的中重度三尖瓣反流的患者预后极其不良

2019-09-07 MedSci MedSci原创

三尖瓣中重度反流的患者,是否进行干预取决于右心室(RV)大小和功能。中重度继发性TR心室重构的机制基本尚未明确。现研究人员对中重度继发性TR患者的心室重构进行研究。本研究共纳入1292位中重度继发性TR患者(中位年龄71岁,男女各一半),采用经胸超声心动图判断其是RV重构状态。根据RV扩张(三尖瓣环≥40mm)和RV收缩功能障碍(三尖瓣环收缩偏移平面<17mm)将RV重构分为4个等级:1级,

三尖瓣中重度反流的患者,是否进行干预取决于右心室(RV)大小和功能。中重度继发性TR心室重构的机制基本尚未明确。现研究人员对中重度继发性TR患者的心室重构进行研究。

本研究共纳入1292位中重度继发性TR患者(中位年龄71岁,男女各一半),采用经胸超声心动图判断其是RV重构状态。根据RV扩张(三尖瓣环≥40mm)和RV收缩功能障碍(三尖瓣环收缩偏移平面<17mm)将RV重构分为4个等级:1级,RV大小和收缩功能正常;2级,RV扩张,但收缩功能正常,3级,RV大小正常,但收缩功能障碍,4级,RV扩张伴收缩功能障碍。主要结点为全因死亡率。

共183位(14%)患者为1级RV重构,256位(20%)患者为2级,304位(24%)为3级,549位(43%)为4级。4级RV重构的患者多为男性,多有冠状动脉疾病,肾功能更差、左心室实射血分数多受累;而且更容易出现症状。在随访过程中,只有98位(8%)患者进行了三尖瓣成形术。中位随访34个月,510位(40%)患者死亡。与1级RV重构的患者相比,3/4级RV重构的患者的5年存活率明显更低(70% vs 52% 和 49%;p=0.002和p<0.001),而且在多变量分析中,与不良预后独立相关。

总而言之,伴有RV收缩功能障碍的中重度继发性TR患者的临床预后较差,无论是否存在RV扩张。

原始出处:

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    2019-09-13 一个字-牛

    学习了谢谢分享

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1692073, encodeId=3b9e16920e36a, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Sun Mar 29 02:31:00 CST 2020, time=2020-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058545, encodeId=9d1c20585456e, content=<a href='/topic/show?id=8a695e2049b' target=_blank style='color:#2F92EE;'>#收缩功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57204, encryptionId=8a695e2049b, topicName=收缩功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Tue Jun 23 09:31:00 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372672, encodeId=66443e26725f, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Sep 13 14:36:28 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407836, encodeId=89e9140e83607, content=<a href='/topic/show?id=f73019633bf' target=_blank style='color:#2F92EE;'>#三尖瓣反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19633, encryptionId=f73019633bf, topicName=三尖瓣反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec6c2728397, createdName=meichuangyi, createdTime=Mon Sep 09 12:31:00 CST 2019, time=2019-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421251, encodeId=4f2514212516a, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Mon Sep 09 12:31:00 CST 2019, time=2019-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571660, encodeId=02eb15e166067, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Mon Sep 09 12:31:00 CST 2019, time=2019-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578472, encodeId=c78e15e8472ce, content=<a href='/topic/show?id=a1021962883' target=_blank style='color:#2F92EE;'>#三尖瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19628, encryptionId=a1021962883, topicName=三尖瓣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c7cb16409801, createdName=124985dbm11(暂无昵称), createdTime=Mon Sep 09 12:31:00 CST 2019, time=2019-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372419, encodeId=dd853e241980, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat Sep 07 21:39:30 CST 2019, time=2019-09-07, status=1, ipAttribution=)]
    2019-09-09 feifers
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    2019-09-07 一个字-牛

    学习了谢谢分享

    0

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