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Cell:肥胖对健康的负面影响不在于脂肪过多而在于功能丧失

2022-02-10 细胞 细胞

脂肪组织功能障碍在疾病中的核心作用和脂肪组织令人难以置信的可塑性支持了为治疗目的调节脂肪组织表型的前景。

众所周知,肥胖会导致高血压糖尿病等心脏代谢疾病,但将这些疾病仅归因于过多的脂肪是一种简化。在基本层面上,脂肪充当储存能量的容器,但仔细观察,它在免疫反应、胰岛素敏感性的调节和体温维持等重要的身体过程中发挥着重要的作用。在发表在202223日的Cell期刊上的一篇标题为“Adipose tissue plasticity in health and disease”的评论类型文章中,研究人员认为,肥胖对健康的负面影响不仅源于脂肪过多,还源于它对变化的反应能力下降,或者换句话说,它的可塑性下降。

图片

脂肪组织可塑性,图片来自Cell, 2022, doi:10.1016/j.cell.2021.12.016

脂肪组织的构成和功能会随着体重波动和衰老而变化。由于衰老和肥胖导致脂肪的可塑性下降,它失去了对身体线索做出反应的能力。在这种现象的当前模型中,脂肪组织的快速生长超过了其血液供应,从而剥夺了脂肪细胞的氧气并导致不再分裂的脂肪细胞堆积。这会导致胰岛素抵抗、炎症和细胞死亡,并伴随着这些细胞中不受控制的脂质溢出。

这些作者说,脂肪组织功能障碍在疾病中的核心作用和脂肪组织令人难以置信的可塑性支持了为治疗目的调节脂肪组织表型的前景。未来仍有许多问题和机会有待发现,这将对脂肪组织生物学产生新的见解,并有希望改善人类疾病的治疗方法。

参考资料:

Alexander Sakers et al. Adipose-tissue plasticity in health and disease. Cell, 2022, doi:10.1016/j.cell.2021.12.016.

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    2022-11-19 维他命
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    2022-02-18 杨玉星

    👍

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1962691, encodeId=5331196269173, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Nov 19 06:33:03 CST 2022, time=2022-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872368, encodeId=45ee18e23680e, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Aug 28 18:33:03 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023382, encodeId=0898202338242, content=<a href='/topic/show?id=0e5f92283c8' target=_blank style='color:#2F92EE;'>#负面影响#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92283, encryptionId=0e5f92283c8, topicName=负面影响)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a244, createdName=d830372, createdTime=Thu Nov 10 21:33:03 CST 2022, time=2022-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1194838, encodeId=128c1194838e6, content=👍 , beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d325499223, createdName=杨玉星, createdTime=Fri Feb 18 17:37:28 CST 2022, time=2022-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1193298, encodeId=2e6c119329839, content=<a href='/topic/show?id=3ad9818917c' target=_blank style='color:#2F92EE;'>#肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81891, encryptionId=3ad9818917c, topicName=肥胖)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Mon Feb 14 13:48:10 CST 2022, time=2022-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1192153, encodeId=313011921536e, content=10000名儿童中就有4-11人患有深度的早, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Feb 11 07:18:03 CST 2022, time=2022-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1192120, encodeId=485f119212013, content=有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/08/20/54886e9842d0997b08ed3f134c538d9d.jpg, createdBy=0d1e1365885, createdName=yesaisai133, createdTime=Thu Feb 10 23:54:12 CST 2022, time=2022-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1192055, encodeId=d39e119205531, content=哇哇哇, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=184a5613511, createdName=ms5000000018187740, createdTime=Thu Feb 10 22:00:42 CST 2022, time=2022-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1192016, encodeId=951e1192016f8, content=受教了,需要减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5f412046808, createdName=蒲公英amy, createdTime=Thu Feb 10 20:59:12 CST 2022, time=2022-02-10, status=1, ipAttribution=)]
    2022-02-11 查查佳佳

    10000名儿童中就有4-11人患有深度的早

    0

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    2022-02-10 yesaisai133

    有帮助

    0

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    2022-02-10 ms5000000018187740

    哇哇哇

    0

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    2022-02-10 蒲公英amy

    受教了,需要减肥

    0

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