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PLOS ONE:警惕:阿司匹林样镇痛药可能导致严重耳聋!

2017-09-06 枫丹白露 来宝网

赖斯大学的一项研究发现,阿司匹林样药物二氟尼柳阻止了prestin的作用,它是听力所需的关键蛋白质。



阿司匹林样镇痛药二氟尼柳阻断听力蛋白】赖斯大学的一项研究发现,阿司匹林样药物二氟尼柳阻止了prestin的作用,它是听力所需的关键蛋白质。

该研究可在开放获取期刊PLOS ONE中在线获得,源自2015年Rice Rice研究,筛选了超过六种非甾体抗炎药或NSAIDs,用于与蛋白质prestin的可能相互作用。 Prestin是一种高度专业化的蛋白质,可以驱动耳蜗中外部毛细胞的作用,耳蜗可以让人们和动物听到声音。

研究主管作者Guillaume Duret是Rice部门的研究科学家,他说:“服用太多的阿司匹林可能导致暂时的耳聋,研究人员发现十多年前发生这种情况是因为水杨酸酯是阿司匹林的主要代谢产物之一,干扰了prestin。“由于以类似于阿司匹林的方式运行的常用NSAID的数量越来越多,确定它们是否也可能抑制prestin似乎是一个好主意。”

Duret说,二氟尼柳是测试中唯一阻止prestin的作用的药物。他说研究结果表明,通过与prestin中的氯离子竞争发生抑制,这种机制类似于水杨酸盐提出的机制。该研究还发现诱导反应所需的剂量小于诱导类似反应所需的阿司匹林剂量。

二氟尼柳主要被认定为轻度止痛药和关节炎的抗炎药。但Duret说,研究结果带来了一个重要时刻,因为医学界正在考虑将二氟尼柳酸重新用作癌症和淀粉样多发性神经病变的可能治疗方法。

Duret说:“到目前为止,它被以药丸形式应用,而已知的副作用是相对较小的剂量,就像您服用阿司匹林一样。 “对于可能注射的较大剂量,副作用可能还不知道。”

他在2015年与两位全球领先的高分子和外毛细胞专家进行了实验研究,分别是Rice生物工程师Rob Raphael和Baylor医学院分子生物学家Fred Pereira。

新发现不容易获得。他们涉及数十次痛苦的实验,其中Duret分离并测量了来自小鼠耳蜗的活的外部毛细胞的活性。为了得到他的测量,Duret必须在显微镜下找到细胞,用玻璃移液管抓住它们,并通过称为全细胞膜片夹钳的过程施加和测量电流。测试必须在存在和不存在二氟苯胺和在短寿命细胞死亡之前进行。

已经研究了超过15年的拉斐尔,并且首先发现了水杨酸盐对prestin的干扰,他说需要进行动物实验来确定二氟尼是否会导致耳聋,何种剂量会导致出现耳聋。

“除了具有潜在的临床意义外,Guillame的精心研究帮助我们改进了我们对分子与prestin的相互作用以及prestin本身如何运作的理解。”Raphael说。

他说,研究还揭示了二氟尼柳对毛细胞膜的直接作用,这可能对其他生理系统有影响。

拉斐尔说:“这项研究来自于像系统和合成生物学这样的新兴领域。”拉斐尔说,实验室正在开发离子传输系统级耳蜗模型。

“这提醒我们,我们对于常用药物如何影响细胞膜中的重要蛋白质仍然没有基本的了解。”他说。 “有时候,即使是你自己的实验室里的发现,也愚弄了我们对生物系统还不了解的程度。”

原始出处:

Guillaume Duret et al, Diflunisal inhibits prestin by chloride-dependent mechanism, PLOS ONE (2017). DOI: 10.1371/journal.pone.0183046.

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    2017-09-08 zhaojie88
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    2017-09-06 131****1460

    学习了受益匪浅.

    0

  5. 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    2017-09-06 圣艮山

    学习了不少事情!

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=241095, encodeId=041c2410957f, content=Prestin是一种高度专业化的蛋白质.可以驱动耳蜗中外部毛细胞的作用.耳蜗可以让人们和动物听到声音., beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 06 18:48:38 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-06 中医痴

    不错的.学习了.谢谢分享!

    0

  7. 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    2017-09-06 随梦飞扬

    二氟尼柳主要被认定为轻度止痛药和关节炎的抗炎药

    0

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    2017-09-06 随梦飞扬

    研究人员发现十多年前发生这种情况是因为水杨酸酯是阿司匹林的主要代谢产物之一.干扰了prestin.

    0

  9. 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    2017-09-06 随梦飞扬

    [服用太多的阿司匹林可能导致暂时的耳聋.

    0

  10. 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createdName=zhaojie88, createdTime=Fri Sep 08 09:05:00 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579726, encodeId=6e6e15e9726b2, content=<a href='/topic/show?id=567c96806cc' target=_blank style='color:#2F92EE;'>#镇痛药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96806, encryptionId=567c96806cc, topicName=镇痛药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef4d16558274, createdName=ms9476844295372110, createdTime=Fri Sep 08 09:05:00 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241136, encodeId=0c2e24113604, content=学习了受益匪浅., beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Sep 06 21:01:12 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241114, encodeId=f88824111446, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Wed Sep 06 19:02:49 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241099, encodeId=2995241099ea, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Wed Sep 06 18:50:47 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241098, encodeId=dc16241098b3, content=二氟尼柳主要被认定为轻度止痛药和关节炎的抗炎药, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 06 18:49:58 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241097, encodeId=e2a024109e1c, content=研究人员发现十多年前发生这种情况是因为水杨酸酯是阿司匹林的主要代谢产物之一.干扰了prestin., beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 06 18:49:24 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241096, encodeId=6b6624109685, content=[服用太多的阿司匹林可能导致暂时的耳聋., beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 06 18:49:08 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241095, encodeId=041c2410957f, content=Prestin是一种高度专业化的蛋白质.可以驱动耳蜗中外部毛细胞的作用.耳蜗可以让人们和动物听到声音., beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 06 18:48:38 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-06 随梦飞扬

    Prestin是一种高度专业化的蛋白质.可以驱动耳蜗中外部毛细胞的作用.耳蜗可以让人们和动物听到声音.

    0

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