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Clinica Chimica Acta：克罗恩病患者肠粘膜上长链非编码RNA及其靶基因的表达变化

2019-09-13 gladiator MedSci原创

上海交通大学医学院附属新华医院研究员/ 副研究员

克罗恩病是一种慢性消化道特发性炎症性疾病。该疾病在全球范围内不断增加，并已成为一个全球性的健康问题。然而，目前关于<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-

克罗恩病是一种慢性消化道特发性炎症性疾病。该疾病在全球范围内不断增加，并已成为一个全球性的健康问题。然而，目前关于CD发病的关键病理机制尚未明确，治疗多为抗症状治疗，疗效非常有限。本研究就lncRNA是否参与CD的发病机制，以及lncRNA在CD过程中如何调控靶基因分析。

研究纳入于2017年5月至2018年5月在东南大学中大医院确诊的患者。收集病理和正常肠粘膜，提取总RNA，利用lncRNA和mRNA基因芯片分析lncRNA和mRNA的表达情况。鉴定并验证了具有显着变化（≥10倍和P <0.05）的lncRNA和mRNA。通过CNC分析揭示具有差异表达的lncRNA的共表达的mRNA。利用miRbase、Targetscan和NCBI数据库，通过Ce (cis/tans)机制分析，确定潜在的调控因素。最后，预测lncRNA-miRNA/TF-mRNA表达网络。

结果显示，8种lncRNA在回肠末端的病理黏膜和正常黏膜中均有差异表达。差异表达的lncRNA的CNC分析显示50个共表达的mRNA为正调节或负调节。通过对mRNAs KEGG通路的分析，发现其中大部分参与了细胞信号通路。细胞质中的6个lncRNA参与了Ce机制，其余两个核中的lncRNA参与了顺式/反式调控机制。最后，通过CNC，KEGG富集分析和Ce（反式/顺式）分析获得了lncRNAs-miRNA和TFs-mRNA的三元关系。

lncRNA在CD黏膜中的差异表达表明lncRNA 参与了免疫反应。这些lncRNAs可能通过lncRNAs-miRNA/TFs-mRNAs的遗传网络参与肠道粘膜功能的调控。

原始出处：

Na Li，Ruihua Shi，Expression alteration of long non-coding RNAs and their target genes in the intestinal mucosa of patients with Crohn’s disease

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2019-09-15 windight

#CTA#

64 0
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2019-12-09 智慧医人

#粘膜#

0 0
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2020-04-03 d830384

#非编码#

77 0
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2019-09-15 chengjn

#靶基因#

88 0
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2019-09-15 minhuang75_72521586

#长链非编码RNA#

68 0
[GetPortalCommentsPageByObjectIdResponse(id=1849694, encodeId=ecbb184969445, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Sep 15 18:41:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691043, encodeId=6281169104387, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Mon Dec 09 14:41:00 CST 2019, time=2019-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743505, encodeId=8bf31e4350544, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Fri Apr 03 13:41:00 CST 2020, time=2020-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313180, encodeId=dcd31313180f5, content=<a href='/topic/show?id=64dd9996046' target=_blank style='color:#2F92EE;'>#靶基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99960, encryptionId=64dd9996046, topicName=靶基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Sun Sep 15 12:41:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485840, encodeId=bd9614858407c, content=<a href='/topic/show?id=d0f29e089a9' target=_blank style='color:#2F92EE;'>#长链非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97089, encryptionId=d0f29e089a9, topicName=长链非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5df38055979, createdName=minhuang75_72521586, createdTime=Sun Sep 15 12:41:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584753, encodeId=ba901584e53b8, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Sun Sep 15 12:41:00 CST 2019, time=2019-09-15, status=1, ipAttribution=)]
2019-09-15 12498f6em12暂无昵称

#编码#

66 0

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