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新疆学者研究称,冠脉“长相难看”,增加动脉粥样硬化风险

2018-08-02 卢芳 中国循环杂志

冠状动脉“长得不好”,粥样硬化风险如何? 新疆医科大学第一附属医院刘文亚、刘晓蓓等研究发现,若左冠状动脉前降支与回旋支间夹角,即左冠状动脉夹角“长得”≥80°,是夹角近段粥样硬化斑块形成的独立危险因素

冠状动脉“长得不好”,粥样硬化风险如何?
 
新疆医科大学第一附属医院刘文亚、刘晓蓓等研究发现,若左冠状动脉前降支与回旋支间夹角,即左冠状动脉夹角“长得”≥80°,是夹角近段粥样硬化斑块形成的独立危险因素。
 
这是在排除年龄、高血压、高血糖、高脂血症、家族史、腰围/身高>0.5、吸烟史的影响后的结果。
 
研究显示,这种“长相”的冠脉在男性更为多见(64.09% vs 43.27%)。
 
而且在左冠状动脉夹角近段有斑块患者中,左冠状动脉夹角≥ 80°的患者,不论男女均比左冠状动脉夹角 <80°者比例高(图1)。
 

图1 左冠状动脉夹角近段有斑块患者中左冠状动脉夹角≥ 80°和<80°不同性别分布
 
进一步进行多因素Logistic 回归分析发现,若男性左冠状动脉夹角≥ 80°,夹角近段发生粥样硬化斑块的风险增加了1.53倍,而对于女性风险更高,增加4.33倍。
 
为什么左冠状动脉夹角≥ 80°,夹角近段粥样硬化风险高?
 
研究者介绍说,由于受到流速、壁面剪切力和血管壁压力的局部血流动力学因素的影响,粥样硬化斑块通常会出现在血管分叉、弯曲以及管腔狭窄处,并且多项研究表明冠状动脉分叉角越大则相应血管管壁壁面剪切力越低,而低的血管壁面剪切力会导致粥样斑块形成。
 
该研究共纳入新疆地区6 所医院 1 276 例行冠脉CT血管造影的患者。
 
原始出处:

刘晓蓓, 潘存雪, 刘文亚.左冠状动脉前降支与回旋支夹角大于 80°与夹角近段动脉粥样硬化的相关性. 中国循环杂志, 2018, 33: 642-641.

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    2018-08-24 jyzxjiangqin

    冠状动脉粥样硬化性心血管疾病。

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    2018-08-12 jyzxjiangqin

    冠状动脉粥样硬化风险。

    0

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    2018-08-02 神功盖世

    0

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