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Int J Dent:炎症介质多态性是否与牙周炎的发生相关?

2017-06-18 MedSci MedSci原创

本研究旨在综合最近荟萃分析——关注炎症介质的多态性及其与牙周炎发展风险的关系——的结果。 检索数据库,纳入2016年10月以前收录的相关文章。三个研究人员提取荟萃分析的文章数据,文章中明确确定炎症介质的基因多态性与牙周炎的发生相关,采用固定或随机统计模型计算比值比,P<0.05为差异有统计学意义。 结果,研究共纳入了13篇荟萃分析文章,包括7个白细胞介素((IL-1A, IL-1B,

本研究旨在综合最近荟萃分析——关注炎症介质的多态性及其与牙周炎发展风险的关系——的结果。

检索数据库,纳入2016年10月以前收录的相关文章。三个研究人员提取荟萃分析的文章数据,文章中明确确定炎症介质的基因多态性与牙周炎的发生相关,采用固定或随机统计模型计算比值比,P<0.05为差异有统计学意义。

结果,研究共纳入了13篇荟萃分析文章,包括7个白细胞介素((IL-1A, IL-1B, IL-4, IL-6, IL-8, IL-10, 和 IL-18),3个细胞受体(Fcγ 受体: FCGR2A, FCGR3A, 和FCGR3B),和5个炎性介质(COX-2、MMP-2、MMP-3、MMP-8,MMP-9)的25个多态性,涉及71531名参与者。

研究结果表明,基因多态性在IL-1A, IL-1B, IL-6, IL-10, MMP-3(慢性型)和MMP-9(慢性型)多态性均与患牙周炎的发生风险有关,而IL-4、IL-8、IL-18、FCγ、COX-2、MMP-2、MMP-3(侵袭型),MMP-8,和MMP-9(侵袭型)多态性与牙周炎的发生风险无明显关联。

原始出处:


Maélson Klever da Silva, Antonio Carlos Gonçalves de Carvalho, et al., Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants. Int J Dent. 2017; 2017: 1914073. Published online 2017 Apr 26. doi:  10.1155/2017/1914073.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1450530, encodeId=cabc1450530bd, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jun 20 03:46:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629216, encodeId=51461629216b1, content=<a href='/topic/show?id=0c1c4325170' target=_blank style='color:#2F92EE;'>#多态性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43251, encryptionId=0c1c4325170, topicName=多态性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d83c21331263, createdName=xzw120, createdTime=Tue Jun 20 03:46:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212379, encodeId=e94e2123e9f6, content=看看了解一下了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sun Jun 18 16:27:55 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212343, encodeId=80e4212343c4, content=重视牙齿保健,选择正规口腔医院, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:04:35 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-20 xzw120
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    2017-06-18 xiaotaiyang1

    看看了解一下了,谢谢

    0

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    2017-06-18 楠博One

    重视牙齿保健,选择正规口腔医院

    0

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