Circulation：胎盘重量和先天性心脏病有什么关系？

2016-10-17 MedSci MedSci原创

既往研究已经表明，先天性心脏病(CHD)与胎盘异常相关。但是我们对这种关联的性质和结局仍然知之甚少。当前这项研究的目的是估计CHD所有的主要亚型和出生时胎盘重量之间的联系，以及胎盘重量和CHD胎儿整体和脑生长测量值之间的关联。研究纳入了1997-2011年出生的924422例丹麦单胎活产儿。7569例存在CHD。校正潜在的混杂因素后，通过多变量线性回归，比较CHD新生儿和非CHD新生儿的胎

既往研究已经表明，先天性心脏病(CHD)与胎盘异常相关。但是我们对这种关联的性质和结局仍然知之甚少。当前这项研究的目的是估计CHD所有的主要亚型和出生时胎盘重量之间的联系，以及胎盘重量和CHD胎儿整体和脑生长测量值之间的关联。

研究纳入了1997-2011年出生的924422例丹麦单胎活产儿。7569例存在CHD。校正潜在的混杂因素后，通过多变量线性回归，比较CHD新生儿和非CHD新生儿的胎盘重量z分的平均差异。

结果表明，CHD与胎盘重量平均z分相差-0.04(95%CI -0.07,-0.02)有关。一些CHD亚型与出生时更小的胎盘有关：法洛四联症 -0.45 (95%CI -0.58, -0.31)，右心室双出口 -0.48 (95%CI -0.87, -0.10)，大的室间隔缺损 -0.41 (95%CI -0.52, -0.29)。出生时胎盘重量z分数与各亚组新生儿的出生体重和头围有关。上述三个亚型中的新生儿，与普通人群的头围和出生体重z分数相比，最高下降达66 %。

结果表明，这三种CHD亚型与更低的胎盘重量有关；此外，胎盘重量和CHD新生儿的整体生长和脑生长相关测量指标有关。

原始出处：

Niels B. Matthiesen,et al.Congenital Heart Defects and Indices of Placental and Fetal Growth in a Nationwide Study of 924,422 Liveborn Infants,Circulation.October 14, 2016

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2016-10-30 镱鉎鉌釚

三种CHD亚型与更低的胎盘重量有关；此外，胎盘重量和CHD新生儿的整体生长和脑生长相关测量指标有关。

203 0
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2016-10-23 1e0ece0dm09(暂无匿称)

谢谢分享学习

176 0
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2016-10-19 huirong

#先天性#

140 0
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2016-10-19 liuyong2981

#胎盘#

131 0
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2016-10-18 1ddc3547m22(暂无匿称)

医学创新，生命神奇

202 0
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2016-10-18 刘煜

谢谢分享。

117 0
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2016-10-18 1de8ed50m80(暂无匿称)

值得一看，是个创新点

179 0
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2016-10-17 Carlos007

这个研究很创新

114 0

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